Inflammatory profiles in sputum and blood of people with TB with and without HIV coinfection

Departments of Medicine, Epidemiology and Global Health. Emory University School of Medicine and Rollins School of Public Health. Atlanta, Georgia, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Organização Multinacional Patrocinadora da Iniciativa de Pesquisa Translacional e Epidemiológica (MONSTER). Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Iniciativa da Organização Multinacional Patrocinadora de Pesquisa Translacional e Epidemiológica (MONSTER). Salvador, BA, Brasil / Faculdade Zarns, Clariens Educação. Instituto de Pesquisa Clínica e Translacional. Salvador, BA, Brasil.
The Aurum Institute. Johannesburg, South Africa / Department of Medicine. Vanderbilt University. Nashville, Tennessee, USA.
The Aurum Institute. Johannesburg, South Africa.
The Aurum Institute. Johannesburg, South Africa.
The Aurum Institute. Johannesburg, South Africa.
Department of Pediatrics. Emory University. Center for CF and Airways Disease Research, Children’s Healthcare of Atlanta. Atlanta, GA, USA.
Department of Pediatrics. Emory University. Center for CF and Airways Disease Research, Children’s Healthcare of Atlanta. Atlanta, GA, USA.
Department of Medicine. University of Massachusetts Chan Medical School. Worcester, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Iniciativa da Organização Multinacional Patrocinadora de Pesquisa Translacional e Epidemiológica (MONSTER). Salvador, BA, Brasil / Faculdade Zarns, Clariens Educação. Instituto de Pesquisa Clínica e Translacional. Salvador, BA, Brasil.
Department of Medicine. Department of Biostatistics, Epidemiology, and Informatics. Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine. University of Pennsylvania. Philadelphia, Pennsylvania, USA.

Abstract

Although tuberculosis (TB) remains a major killer among infectious diseases and the leading cause of death for people with HIV, drivers of immunopathology, particularly at the site of infection in the lungs remain incompletely understood. To fill this gap, we compared cytokine profiles in paired plasma and sputum samples collected from adults with pulmonary TB with and without HIV. We found that people with pulmonary TB with HIV had significantly higher markers of inflammation in both plasma and sputum than those without HIV; these differences were present despite a similar extent of radiographic involvement. We also found that the strength and direction of correlations between biomarkers in the blood and lung compartments differed by HIV status and people with HIV had more positive correlations than those without HIV. Future studies can further explore these differences in inflammation by HIV status across the blood and lung compartments and seek to establish how these profiles may be associated with long-term outcomes and lung health after completion of TB treatment.

Keywords in Portuguese

Escarro
Sangue
Infecções por HIV
Tuberculose

Keywords

Sputum
Blood
HIV Infections
Tuberculosis

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Cold Spring Harbor Laboratory

Citation

AULD, Sara C. et al. Inflammatory profiles in sputum and blood of people with TB with and without HIV coinfection. medRxiv, p. 1-13, 2024.

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/69576

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