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https://www.arca.fiocruz.br/handle/icict/69620
CARDIAC BIOMARKERS IN A BRAZILIAN INDIGENOUS POPULATION EXPOSED TO ARBOVIRUSES: A CROSS-SECTIONAL STUDY
Author
Nicacio, Jandir Mendonça
Souza, Carlos Dornels Freire de
Gomes, Orlando Vieira
Souza, Beatriz Vasconcelos
Lima, João Augusto Costa
Carmo, Rodrigo Feliciano do
Nunes, Sávio Luiz Pereira
Pereira, Vanessa Cardoso
Barros, Naiara de Souza
Melo, Ana Luiza Santos de
Lourencini, Lucca Gabriel Feitosa
Magalhães, Jurandy Júnior Ferraz de
Cabral, Diego Guerra de Albuquerque
Khouri, Ricardo
Barral-Netto, Manoel
Armstrong, Anderson da Costa
Souza, Carlos Dornels Freire de
Gomes, Orlando Vieira
Souza, Beatriz Vasconcelos
Lima, João Augusto Costa
Carmo, Rodrigo Feliciano do
Nunes, Sávio Luiz Pereira
Pereira, Vanessa Cardoso
Barros, Naiara de Souza
Melo, Ana Luiza Santos de
Lourencini, Lucca Gabriel Feitosa
Magalhães, Jurandy Júnior Ferraz de
Cabral, Diego Guerra de Albuquerque
Khouri, Ricardo
Barral-Netto, Manoel
Armstrong, Anderson da Costa
Affilliation
Faculty of Medicine, Federal University of Vale do São Francisco-UNIVASF, Petrolina, PE, Brazil.
Postgraduate Program in Human Ecology and Socio-Environmental Management, Bahia State University-UNEB, Juazeiro, BA, Brazil.
Faculty of Medicine, Federal University of Vale do São Francisco-UNIVASF, Petrolina, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
Faculty of Medicine, Federal University of Vale do São Francisco-UNIVASF, Petrolina, PE, Brazil.
Postgraduate Program in Human Ecology and Socio-Environmental Management, Bahia State University-UNEB, Juazeiro, BA, Brazil.
ostgraduate Program in Human Pathology, Faculty of Medicine of Bahia, Federal University of Bahia, Salvador, BA, Brazil.
Cardiology, Johns Hopkins University, Baltimore, MD 21205, USA.
Faculty of Medicine, Federal University of Vale do São Francisco-UNIVASF, Petrolina, PE, Brazil.
Postgraduate Program in Applied Cellular and Molecular Biology, University of Pernambuco-UPE, Recife, PE, Brazil.
Postgraduate Program in Human Ecology and Socio-Environmental Management, Bahia State University-UNEB, Juazeiro, BA, Brazil.
Collegiate of Medicine, Faculty of Medicine, Federal University of Vale do São Francisco-UNIVASF, Petrolina Campus, Petrolina, PE, Brazil.
Collegiate of Medicine, Faculty of Medicine, Federal University of Vale do São Francisco-UNIVASF, Petrolina Campus, Petrolina, PE, Brazil.
Collegiate of Medicine, Faculty of Medicine, Federal University of Vale do São Francisco-UNIVASF, Petrolina Campus, Petrolina, PE, Brazil.
College of Medicine-Serra Talhada Campus-UPE/ST, University of Pernambuco, Serra Talhada, PE, Brazil.
Agamenon Magalhães Hospital, Serra Talhada, PE, Brazil.
Central Public Health Laboratory of Pernambuco-LACEN, Recife, PE, Brazil.
Oswaldo Cruz Foundation/Fiocruz, Institute Gonçalo Moniz, Salvador, BA, Brazil.
School of Medicine, Federal University of Bahia-UFBA, Salvador, BA, Brazil.
Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium.
School of Medicine, Federal University of Bahia-UFBA, Salvador, BA, Brazil.
Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia, University of São Paulo, São Paulo , SP, Brazil.
Faculty of Medicine, Federal University of Vale do São Francisco-UNIVASF, Petrolina, PE, Brazil.
Postgraduate Program in Human Ecology and Socio-Environmental Management, Bahia State University-UNEB, Juazeiro, BA, Brazil.
Postgraduate Program in Human Ecology and Socio-Environmental Management, Bahia State University-UNEB, Juazeiro, BA, Brazil.
Faculty of Medicine, Federal University of Vale do São Francisco-UNIVASF, Petrolina, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
Faculty of Medicine, Federal University of Vale do São Francisco-UNIVASF, Petrolina, PE, Brazil.
Postgraduate Program in Human Ecology and Socio-Environmental Management, Bahia State University-UNEB, Juazeiro, BA, Brazil.
ostgraduate Program in Human Pathology, Faculty of Medicine of Bahia, Federal University of Bahia, Salvador, BA, Brazil.
Cardiology, Johns Hopkins University, Baltimore, MD 21205, USA.
Faculty of Medicine, Federal University of Vale do São Francisco-UNIVASF, Petrolina, PE, Brazil.
Postgraduate Program in Applied Cellular and Molecular Biology, University of Pernambuco-UPE, Recife, PE, Brazil.
Postgraduate Program in Human Ecology and Socio-Environmental Management, Bahia State University-UNEB, Juazeiro, BA, Brazil.
Collegiate of Medicine, Faculty of Medicine, Federal University of Vale do São Francisco-UNIVASF, Petrolina Campus, Petrolina, PE, Brazil.
Collegiate of Medicine, Faculty of Medicine, Federal University of Vale do São Francisco-UNIVASF, Petrolina Campus, Petrolina, PE, Brazil.
Collegiate of Medicine, Faculty of Medicine, Federal University of Vale do São Francisco-UNIVASF, Petrolina Campus, Petrolina, PE, Brazil.
College of Medicine-Serra Talhada Campus-UPE/ST, University of Pernambuco, Serra Talhada, PE, Brazil.
Agamenon Magalhães Hospital, Serra Talhada, PE, Brazil.
Central Public Health Laboratory of Pernambuco-LACEN, Recife, PE, Brazil.
Oswaldo Cruz Foundation/Fiocruz, Institute Gonçalo Moniz, Salvador, BA, Brazil.
School of Medicine, Federal University of Bahia-UFBA, Salvador, BA, Brazil.
Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium.
School of Medicine, Federal University of Bahia-UFBA, Salvador, BA, Brazil.
Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia, University of São Paulo, São Paulo , SP, Brazil.
Faculty of Medicine, Federal University of Vale do São Francisco-UNIVASF, Petrolina, PE, Brazil.
Postgraduate Program in Human Ecology and Socio-Environmental Management, Bahia State University-UNEB, Juazeiro, BA, Brazil.
Abstract
Arthropod-borne viral diseases are acute febrile illnesses, sometimes with chronic effects, that can be debilitating and even fatal worldwide, affecting particularly vulnerable populations. Indigenous communities face not only the burden of these acute febrile illnesses, but also the cardiovascular complications that are worsened by urbanization. A cross-sectional study was conducted in an Indigenous population in the Northeast Region of Brazil to explore the association between arboviral infections (dengue, chikungunya, and Zika) and cardiac biomarkers, including cardiotrophin 1, growth differentiation factor 15, lactate dehydrogenase B, fatty-acid-binding protein 3, myoglobin, N-terminal pro-B-type natriuretic peptide, cardiac troponin I, big endothelin 1, and creatine kinase-MB, along with clinical and anthropometric factors. The study included 174 individuals from the Fulni-ô community, with a median age of 47 years (interquartile range 39.0 to 56.0). High rates of previous exposure to dengue, chikungunya, and Zika were observed (92.5%, 78.2%, and 95.4% anti-IgG, respectively), while acute exposure (anti-IgM) remained low. The biomarkers were linked to age (especially in the elderly), obesity, chronic kidney disease, and previous or recent exposure to chikungunya. This study pioneers the use of Luminex xMAP technology to reveal the association between cardiac inflammatory biomarkers and exposure to classical arboviruses in an Indigenous population undergoing urbanization.
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