| Author | Anders, Katherine L | |
| Author | Ribeiro, Gabriel Sylvestre | |
| Author | Lopes, Renato da Silva | |
| Author | Amadeu, Pilar | |
| Author | Costa, Thiago Rodrigues da | |
| Author | Riback, Thais Irene Souza | |
| Author | Chalegre, Karlos Diogo de Melo | |
| Author | Oliveira, Wesley Pimentel de | |
| Author | Silva, Cátia Cabral da | |
| Author | Blanco, Marcos B Vinicius Ferreira Mendes | |
| Author | Eppinghaus, Ana Lucia Fontes | |
| Author | Boas, Fabio Villas | |
| Author | Frossard, Tibor | |
| Author | Green, Benjamin R | |
| Author | O’Neill, Scott L | |
| Author | Ryan, Peter A | |
| Author | Simmons, Cameron P | |
| Author | Moreira, Luciano Andrade | |
| Access date | 2025-04-29T17:52:44Z | |
| Available date | 2025-04-29T17:52:44Z | |
| Document date | 2025 | |
| Citation | ANDERS, Katherine L. et al. Long-term durability and public health impact of city-wide w Mel Wolbachia mosquito releases in Niterói, Brazil during a dengue epidemic surge. medRxiv, p. 2025-04, 2025. | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/69991 | |
| Language | eng | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Dengue | en_US |
| Title | Long-term durability and public health impact of city-wide w Mel Wolbachia mosquito releases in Niterói, Brazil during a dengue epidemic surge. | en_US |
| Type | Preprint | en_US |
| Abstract | In 2024, the Americas region experienced the largest dengue outbreak on record and Brazil was among the worst affected countries, reporting 6.6 million cases and 6,200 deaths. We report the long-term entomological and epidemiological effectiveness of city-wide deployment of wMel-strain Wolbachia-infected Aedes aegypti in Niterói, a city of half a million people in Rio de Janeiro state, where Wolbachia releases across 70% of the urban population in 2017-2019 were expanded to remaining populated areas in 2023. wMel was durably established at ≥95% prevalence in Ae. aegypti populations throughout Niterói four years post-release, and up to seven years in the earliest release sites. This city-wide Wolbachia coverage provided sustained population-level protection against dengue throughout the five years post-intervention, including during the 2024 epidemic surge, averting an estimated three-quarters of the dengue case burden that would otherwise have been expected in Niterói in 2024. | en_US |
| Affilliation | World Mosquito Program. Melbourne, Victoria, Australia. / Monash University School of Public Health and Preventive Medicine. Melbourne, Victoria, Australia. | en_US |
| Affilliation | World Mosquito Program. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | World Mosquito Program. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | World Mosquito Program. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | World Mosquito Program. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | World Mosquito Program. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | World Mosquito Program. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | World Mosquito Program. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | World Mosquito Program. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | World Mosquito Program. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Prefeitura do Rio de Janeiro. Secretaria Municipal de Saúde. Niterói, RJ, Brasil. | en_US |
| Affilliation | Prefeitura do Rio de Janeiro. Secretaria Municipal de Saúde. Niterói, RJ, Brasil. | en_US |
| Affilliation | World Mosquito Program. Melbourne, Victoria, Australia. | en_US |
| Affilliation | World Mosquito Program. Melbourne, Victoria, Australia. | en_US |
| Affilliation | World Mosquito Program. Melbourne, Victoria, Australia. | en_US |
| Affilliation | World Mosquito Program. Melbourne, Victoria, Australia. | en_US |
| Affilliation | World Mosquito Program. Melbourne, Victoria, Australia. | en_US |
| Affilliation | World Mosquito Program. Rio de Janeiro, RJ, Brasil. / Fundação Oswaldo Cruz. Instituto René Rachou, Belo Horizonte. Belo Horizonte, MG, Brasil. | en_US |
