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LONG-TERM DURABILITY AND PUBLIC HEALTH IMPACT OF CITY-WIDE W MEL WOLBACHIA MOSQUITO RELEASES IN NITERÓI, BRAZIL DURING A DENGUE EPIDEMIC SURGE.
Anders, Katherine L et al. | Date Issued: 2025
Author
Anders, Katherine L
Ribeiro, Gabriel Sylvestre
Lopes, Renato da Silva
Amadeu, Pilar
Costa, Thiago Rodrigues da
Riback, Thais Irene Souza
Chalegre, Karlos Diogo de Melo
Oliveira, Wesley Pimentel de
Silva, Cátia Cabral da
Blanco, Marcos B Vinicius Ferreira Mendes
Eppinghaus, Ana Lucia Fontes
Boas, Fabio Villas
Frossard, Tibor
Green, Benjamin R
O’Neill, Scott L
Ryan, Peter A
Simmons, Cameron P
Moreira, Luciano Andrade
Affilliation
World Mosquito Program. Melbourne, Victoria, Australia. / Monash University School of Public Health and Preventive Medicine. Melbourne, Victoria, Australia.
World Mosquito Program. Rio de Janeiro, RJ, Brasil.
World Mosquito Program. Rio de Janeiro, RJ, Brasil.
World Mosquito Program. Rio de Janeiro, RJ, Brasil.
World Mosquito Program. Rio de Janeiro, RJ, Brasil.
World Mosquito Program. Rio de Janeiro, RJ, Brasil.
World Mosquito Program. Rio de Janeiro, RJ, Brasil.
World Mosquito Program. Rio de Janeiro, RJ, Brasil.
World Mosquito Program. Rio de Janeiro, RJ, Brasil.
World Mosquito Program. Rio de Janeiro, RJ, Brasil.
Prefeitura do Rio de Janeiro. Secretaria Municipal de Saúde. Niterói, RJ, Brasil.
Prefeitura do Rio de Janeiro. Secretaria Municipal de Saúde. Niterói, RJ, Brasil.
World Mosquito Program. Melbourne, Victoria, Australia.
World Mosquito Program. Melbourne, Victoria, Australia.
World Mosquito Program. Melbourne, Victoria, Australia.
World Mosquito Program. Melbourne, Victoria, Australia.
World Mosquito Program. Melbourne, Victoria, Australia.
World Mosquito Program. Rio de Janeiro, RJ, Brasil. / Fundação Oswaldo Cruz. Instituto René Rachou, Belo Horizonte. Belo Horizonte, MG, Brasil.
Abstract
In 2024, the Americas region experienced the largest dengue outbreak on record and Brazil was among the worst affected countries, reporting 6.6 million cases and 6,200 deaths. We report the long-term entomological and epidemiological effectiveness of city-wide deployment of wMel-strain Wolbachia-infected Aedes aegypti in Niterói, a city of half a million people in Rio de Janeiro state, where Wolbachia releases across 70% of the urban population in 2017-2019 were expanded to remaining populated areas in 2023. wMel was durably established at ≥95% prevalence in Ae. aegypti populations throughout Niterói four years post-release, and up to seven years in the earliest release sites. This city-wide Wolbachia coverage provided sustained population-level protection against dengue throughout the five years post-intervention, including during the 2024 epidemic surge, averting an estimated three-quarters of the dengue case burden that would otherwise have been expected in Niterói in 2024.
Keywords in Portuguese
Dengue
Citation
ANDERS, Katherine L. et al. Long-term durability and public health impact of city-wide w Mel Wolbachia mosquito releases in Niterói, Brazil during a dengue epidemic surge. medRxiv, p. 2025-04, 2025.