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IMMUNIZATION WITH NEWLY TRANSFORMED SCHISTOSOMA MANSONI SCHISTOSOMULA TEGUMENT ELICITS TEGUMENT DAMAGE, REDUCTION IN EGG AND PARASITE BURDEN
Melo, Tatiane Teixeira de et al. | Date Issued: 2010
Author
Melo, Tatiane Teixeira de
Araújo, Juliano Michel de
Durães, Fernanda do Valle
Caliari, Marcelo Vidigal
Oliveira, Sérgio Costa
Coelho, Paulo Marcos Zach
Fonseca, Cristina Toscano
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil / Instituto Nacional de Ciências e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.
Abstract
The surface of the schistosomula is an important target for host immune system attack because the tegument represents the interface between host and parasite and thus is a poten-tial candidate for the development of new intervention strategies. In this study, we evaluated the ability of schisto-somula tegument (Smteg) to induce protection in mice. Immunization of mice with Smteg together with Freund adjuvant induced a Th1 type of immune response associated with a significant reduction in worm burden (43–48%), eggs trapped in the liver (65%), eggs eliminated in the faeces (59–60%) and granuloma number (41%). Lastly, during na in vitro study, worms from mice immunized with Smteg showed damage in the adult worm tegument and impaired egg laying
Keywords
Schistosoma mansoni
schistosomula tegument
Vaccine
 
Publisher
Blackwell Scientific Publications
Citation
MELO, Tatiane Teixeira de et al. Immunization with newly transformed Schistosoma mansoni schistosomula tegument elicits tegument damage, reduction in egg and parasite burden. Parasite Immunol., v. 32, n. 11-12, p. 749-759, Nov./Dec. 2010.
DOI
10.1111/j.1365-3024.2010.01244.x
ISSN
0141-983