Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7079
Title: Ageing Down-Modulates Liver Inflammatory Immune Responses to Schistosome Infection in Mice
Authors: Faria, Elaine Speziali de
Aranha, Claudio Henrique Magalhães
Carvalho, Andréa Teixeira de
Santiago, Andrezza Fernanda
Oliveira, Rafael Pires de
Rezende, Michelle Carvalho de
Carneiro, Cláudia Martins
Corrêa, Deborah Aparecida Negrão
Coelho, Paulo Marcos Zach
Faria, Ana Maria Caetano de
Affilliation: Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, Brasil/Universidade Vale do Rio Doce. Nucleo de Pesquisa em Imunologia. Governador Valadares, MG, Brazil
Universidade Federal de Ouro Preto. Nucleo de Pesquisa em Ciencias Biologicas. Laboratorio de Imunopatologia. Ouro Preto, Brazil/Universidade Vale do Rio Doce. Nucleo de Pesquisa em Imunologia. Governador Valadares, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia. Belo Horizonte, MG, Brazil
Universidade Federal de Ouro Preto. Nucleo de Pesquisa em Ciencias Biologicas. Laboratorio de Imunopatologia. Ouro Preto, Brazil
Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, Brasil
Abstract: Ageing is associated with several alterations in the immune system. Our aim in this study was to compare the development of immunity to Schistosoma mansoni infection in young versus aged C57Bl/6 mice using the liver as the main organ to evaluate pathological alterations and immune responses. In the acute phase, young mice had large liver granulomas with fibrosis and inflammatory cells. Chronic phase in young animals was associated with immunomodulation of granulomas that became reduced in size and cellular infiltrate. On the other hand, aged animals presented granulomas of smaller sizes already in the acute phase. Chronic infection in these mice was followed by no alteration in any of the inflammatory parameters in the liver. In concert with this finding, there was an increase in activated CD4+ T, CD19+ B and NK liver cells in young mice after infection whereas old mice had already higher frequencies of activated B, NK and CD4+ T liver cells and infection does not change these frequencies. After infection, liver production of inflammatory and regulatory cytokines such as IFN-gamma, IL-4 and IL-10 increased in young but not in old mice that had high levels of IL-4 and IL-10 regardless of their infection status. Our data suggest that the unspecific activation status of the immune system in aged mice impairs inflammatory as well as regulatory immune responses to S. mansoni infection in the liver, where major pathological alterations and immunity are at stage. This poor immune reactivity may have a beneficial impact on disease development.
Keywords: Cytokines/immunology
Flow Cytometry
Inflammation/immunology
Inflammation/pathology
Schistosomiasis mansoni/immunologyy
Schistosomiasis mansoni/pathology
Issue Date: 2010
Publisher: Blackwell Scientific Publications
Citation: FARIA, Elaine Speziali de et al. Ageing Down-Modulates Liver Inflammatory Immune Responses to Schistosome Infection in Mice. Scand J Immunol., v. 71, n. 4, p. 240-248, Apr. 2010.
DOI: 10.1111/j.1365-3083.2010.02370.x
ISSN: 0300-9475
Copyright: restricted access
Appears in Collections:MG - IRR - Artigos de Periódicos

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