| Author | Ferrari, Teresa Cristina de Abreu | |
| Author | Moreira, Paulo Roberto Rocha | |
| Author | Sampaio, Márcio José | |
| Author | Cunha, Aloísio Sales da | |
| Author | Oliveira, José Teotônio de | |
| Author | Gazzinelli, Giovanni | |
| Author | Oliveira, Rodrigo Correa de | |
| Access date | 2013-10-11T14:01:27Z | |
| Available date | 2013-10-11T14:01:27Z | |
| Document date | 2006 | |
| Citation | FERRARI, Teresa Cristina Abreu et al. Intrathecal cytokines in spinal cord schistosomiasis. J Neuroimmunol. 2006 Aug;177(1-2):136-41 | pt_BR |
| ISSN | 0165-5728 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7118 | |
| Language | eng | pt_BR |
| Publisher | Elsevier/North-Holland | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Intrathecal cytokines in spinal cord schistosomiasis | pt_BR |
| Type | Article | pt_BR |
| Abstract | We investigate the cytokine profile in the cerebrospinal fluid (CSF) and serum of patients with spinal cord schistosomiasis (SCS). Increased levels of IL-1β, IL-4, IL-6 and IL-10 and low concentrations of TNF-αand IFN-γwere observed in both CSF and serum. CSF showed higher levels of IL-4 and IL-6 when compared to the paired serum samples. A negative correlation between the concentrations of IL-10 and IFN-γwas observed in the CSF. These findings suggest an inflammatory as well as a skewed type-2 immune response that probably occur both locally and systemically and may be involved in the pathogenesis of SCS. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Hospital das Clínicas. Serviço de Neurologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Hospital das Clínicas. Serviço de Neurologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil | pt_BR |
| Subject | Neuroschistosomiasis | pt_BR |
| Subject | Spinal cord disease | pt_BR |
| Subject | Cytokines | pt_BR |
| Subject | Cerebrospinal fluid | pt_BR |
| Subject | Schistosoma mansoni | pt_BR |
