Author | Nonato, Fabiana Regina | |
Author | Santana, Danielle Gomes | |
Author | Melo, Flavielle Martins de | |
Author | Santos, Gisele Graça Leite dos | |
Author | Brustolim, Daniele | |
Author | Camargo, Enilton A. | |
Author | Sousa, Damião P. de | |
Author | Soares, Milena Botelho Pereira | |
Author | Villarreal, Cristiane Flora | |
Access date | 2013-11-13T16:54:35Z | |
Available date | 2013-11-13T16:54:35Z | |
Document date | 2012 | |
Citation | NONATO, F. R. et al. Anti-inflammatory properties of rose oxide. International Immunopharmacology, v. 14, p. 779–784, 2012. | pt_BR |
ISSN | 1567-5769 | |
URI | https://www.arca.fiocruz.br/handle/icict/7232 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Title | Anti-inflammatory properties of rose oxide | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.intimp.2012.10.015 | |
Abstract | Rose-oxide is a fragrance found in roses and rose oil. There are no reports about the pharmacological activity of
this molecule. The present study was undertaken to evaluate whether rose-oxide (RO) has anti-inflammatory
properties and to investigate possible mechanisms involved with its effects. The anti-inflammatory activity
of RO was first suggested by the formalin test in mice, an inflammatory pain model, because intraperitoneal
(i.p.) administration of RO (50 and 100 mg/kg) inhibited only the late phase of this test. To further investigate
the anti-inflammatory properties of RO, the complete Freund's adjuvant (CFA)- and carrageenan-induced paw
inflammation models were used. Pre-treatment with RO (50 and 100 mg/kg) significantly reduced paw
edema at 4, 6 and 24 h after the CFA injection. In addition, RO (100 mg/kg) reduced the IL-1β, but not
TNF-α, local production induced by CFA. Administration of RO (25–100 mg/kg) decreased the paw edema
induced by carrageenan in rats, which was more evident at 3 and 4 h after induction. In addition, neutrophil
migration to the hind paw was measured by MPO assay after the carrageenan injection. The MPO activity was
significantly inhibited by RO at 25–100 mg/kg, 4 h after stimulus. In another experimental set, administration
of RO (25–100 mg/kg) significantly reduced the leukocyte migration in the carrageenan-induced peritonitis
model in mice. The results described here are the first report of pharmacological properties of RO and strongly
suggest that RO possesses anti-inflammatory activity related to its ability to inhibit the IL-1β production and
the leukocyte migration. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, Sergipe, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, Bahia, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, Sergipe, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, Sergipe, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, Bahia, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, Bahia, Brasil | pt_BR |
Subject | Essential oils | pt_BR |
Subject | Monoterpenes | pt_BR |
Subject | Anti-inflammatory | pt_BR |
Subject | Cytokines | pt_BR |