Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7232
Title: Anti-inflammatory properties of rose oxide
Authors: Nonato, Fabiana Regina
Santana, Danielle Gomes
Melo, Flavielle Martins de
Santos, Gisele Graça Leite dos
Brustolim, Daniele
Camargo, Enilton A.
Sousa, Damião P. de
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, Sergipe, Brasil
Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, Sergipe, Brasil
Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, Sergipe, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, Bahia, Brasil
Abstract: Rose-oxide is a fragrance found in roses and rose oil. There are no reports about the pharmacological activity of this molecule. The present study was undertaken to evaluate whether rose-oxide (RO) has anti-inflammatory properties and to investigate possible mechanisms involved with its effects. The anti-inflammatory activity of RO was first suggested by the formalin test in mice, an inflammatory pain model, because intraperitoneal (i.p.) administration of RO (50 and 100 mg/kg) inhibited only the late phase of this test. To further investigate the anti-inflammatory properties of RO, the complete Freund's adjuvant (CFA)- and carrageenan-induced paw inflammation models were used. Pre-treatment with RO (50 and 100 mg/kg) significantly reduced paw edema at 4, 6 and 24 h after the CFA injection. In addition, RO (100 mg/kg) reduced the IL-1β, but not TNF-α, local production induced by CFA. Administration of RO (25–100 mg/kg) decreased the paw edema induced by carrageenan in rats, which was more evident at 3 and 4 h after induction. In addition, neutrophil migration to the hind paw was measured by MPO assay after the carrageenan injection. The MPO activity was significantly inhibited by RO at 25–100 mg/kg, 4 h after stimulus. In another experimental set, administration of RO (25–100 mg/kg) significantly reduced the leukocyte migration in the carrageenan-induced peritonitis model in mice. The results described here are the first report of pharmacological properties of RO and strongly suggest that RO possesses anti-inflammatory activity related to its ability to inhibit the IL-1β production and the leukocyte migration.
Keywords: Essential oils
Monoterpenes
Anti-inflammatory
Cytokines
Issue Date: 2012
Publisher: Elsevier
Citation: NONATO, F. R. et al. Anti-inflammatory properties of rose oxide. International Immunopharmacology, v. 14, p. 779–784, 2012.
DOI: 10.1016/j.intimp.2012.10.015
ISSN: 1567-5769
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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