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https://www.arca.fiocruz.br/handle/icict/7232
ANTI-INFLAMMATORY PROPERTIES OF ROSE OXIDE
Author
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, Sergipe, Brasil
Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, Sergipe, Brasil
Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, Sergipe, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, Bahia, Brasil
Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, Sergipe, Brasil
Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, Sergipe, Brasil
Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, Sergipe, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, Bahia, Brasil
Abstract
Rose-oxide is a fragrance found in roses and rose oil. There are no reports about the pharmacological activity of
this molecule. The present study was undertaken to evaluate whether rose-oxide (RO) has anti-inflammatory
properties and to investigate possible mechanisms involved with its effects. The anti-inflammatory activity
of RO was first suggested by the formalin test in mice, an inflammatory pain model, because intraperitoneal
(i.p.) administration of RO (50 and 100 mg/kg) inhibited only the late phase of this test. To further investigate
the anti-inflammatory properties of RO, the complete Freund's adjuvant (CFA)- and carrageenan-induced paw
inflammation models were used. Pre-treatment with RO (50 and 100 mg/kg) significantly reduced paw
edema at 4, 6 and 24 h after the CFA injection. In addition, RO (100 mg/kg) reduced the IL-1β, but not
TNF-α, local production induced by CFA. Administration of RO (25–100 mg/kg) decreased the paw edema
induced by carrageenan in rats, which was more evident at 3 and 4 h after induction. In addition, neutrophil
migration to the hind paw was measured by MPO assay after the carrageenan injection. The MPO activity was
significantly inhibited by RO at 25–100 mg/kg, 4 h after stimulus. In another experimental set, administration
of RO (25–100 mg/kg) significantly reduced the leukocyte migration in the carrageenan-induced peritonitis
model in mice. The results described here are the first report of pharmacological properties of RO and strongly
suggest that RO possesses anti-inflammatory activity related to its ability to inhibit the IL-1β production and
the leukocyte migration.
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