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Title: Challenges in the research and development of new human vaccines
Authors: Bessa, Theolis Costa Barbosa
Barral Netto, Manoel
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Abstract: The field of vaccinology was born from the observations by the fathers of vaccination, Edward Jenner and Louis Pasteur, that a permanent, positive change in the way our bodies respond to life-threatening infectious diseases can be obtained by specific challenge with the inactivated infectious agent performed in a controlled manner, avoiding the development of clinical disease upon exposure to the virulent pathogen. Many of the vaccines still in use today were developed on an empirical basis, essentially following the paradigm established by Pasteur, ‘‘isolate, inactivate, and inject’’ the disease-causing microorganism, and are capable of eliciting uniform, long-term immune memory responses that constitute the key to their proven efficacy. However, vaccines for pathogens considered as priority targets of public health concern are still lacking. The literature tends to focus more often on vaccine research problems associated with specific pathogens, but it is increasingly clear that there are common bottlenecks in vaccine research, which need to be solved in order to advance the development of the field as a whole. As part of a group of articles, the objective of the present report is to pinpoint these bottlenecks, exploring the literature for common problems and solutions in vaccine research applied to different situations. Our goal is to stimulate brainstorming among specialists of different fields related to vaccine research and development. Here, we briefly summarize the topics we intend to deal with in this discussion.
Keywords: Human vaccines
Vaccine issues
Vaccine efficacy
Immunization strategies
Issue Date: 2013
Publisher: Faculdade de Medicina de Ribeirao Preto
Citation: BARBOSA, T.; BARBOSA, T. Challenges in the research and development of new human vaccines. Brazilian Journal of Medical and Biological Research, v. 46, n. 2, p.103-108, 2013.
DOI: 10.1590/1414-431X20131873
ISSN: 1414-431X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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