| Author | Sá, Matheus Santos de | |
| Author | Menezes, Maria N. de | |
| Author | Krettli, Antoniana Ursini | |
| Author | Ribeiro, Ivone Maria | |
| Author | Tomassini, Therezinha Coelho Barbosa | |
| Author | Santos, Ricardo Ribeiro dos | |
| Author | Azevedo Junior, Walter Filgueira de | |
| Author | Soares, Milena Botelho Pereira | |
| Access date | 2014-02-07T17:36:59Z | |
| Available date | 2014-02-07T17:36:59Z | |
| Document date | 2011 | |
| Citation | SÁ, M. S. et al. Antimalarial activity of physalins B, D, F, and G. Journal of Natural Products, v. 74, n. 10, p. 2269-2272, 2011. | pt_BR |
| ISSN | 1520-6025 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7299 | |
| Language | eng | pt_BR |
| Publisher | American Chemical Society and American Society of Pharmacognosy | pt_BR |
| Rights | open access | pt_BR |
| Title | Antimalarial activity of physalins B, D, F, and G | pt_BR |
| Type | Article | pt_BR |
| DOI | dx.doi.org/10.1021/np200260f | | |
| Abstract | The antimalarial activities of physalins B, D, F, and G (1−4), isolated from
Physalis angulata, were investigated. In silico analysis using the similarity ensemble
approach (SEA) database predicted the antimalarial activity of each of these compounds,
which were shown using an in vitro assay against Plasmodium falciparum. However,
treatment of P. berghei-infected mice with 3 increased parasitemia levels and mortality,
whereas treatment with 2 was protective, causing a parasitemia reduction and a delay in
mortality in P. berghei-infected mice. The exacerbation of in vivo infection by treatment
with 3 is probably due to its potent immunosuppressive activity, which is not evident for 2 | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, Minas Gerais, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. FarManguinhos. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. FarManguinhos. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil | pt_BR |
| Affilliation | Pontificia Universidade Católica. LaBioQuest-Faculdade de Biociencias. Porto Alegre, RS, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil | pt_BR |
| DeCS | Antimaláricos/farmacologia | pt_BR |
| DeCS | Imunossupressores/farmacologia | pt_BR |
| DeCS | Physalis/química | pt_BR |
| DeCS | Plasmodium berghei/efeitos de drogas | pt_BR |
| DeCS | Plasmodium falciparum/efeitos de drogas | pt_BR |
| DeCS | Secoesteroides/farmacologia | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Antimaláricos/química | pt_BR |
| DeCS | Antimaláricos/isolamento & purificação | pt_BR |
| DeCS | Imunossupressores/química | pt_BR |
| DeCS | Imunossupressores/isolamento & purificação | pt_BR |
| DeCS | Malária/quimioterapia | pt_BR |
| DeCS | Camundongos | pt_BR |
| DeCS | Camundongos Endogâmicos BALB C | pt_BR |
| DeCS | Parasitemia/quimioterapia | pt_BR |
| DeCS | Secoesteroides/química | pt_BR |
| DeCS | Secoesteroides/isolamento & purificação | pt_BR |
