Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7299
Title: Antimalarial activity of physalins B, D, F, and G
Authors: Sá, Matheus Santos de
Menezes, Maria N. de
Krettli, Antoniana Ursini
Ribeiro, Ivone Maria
Tomassini, Therezinha Coelho Barbosa
Santos, Ricardo Ribeiro dos
Azevedo Junior, Walter Filgueira de
Soares, Milena Botelho Pereira
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, Minas Gerais, Brasil
Fundação Oswaldo Cruz. FarManguinhos. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. FarManguinhos. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil
Pontificia Universidade Católica. LaBioQuest-Faculdade de Biociencias. Porto Alegre, RS, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil
Abstract: The antimalarial activities of physalins B, D, F, and G (1−4), isolated from Physalis angulata, were investigated. In silico analysis using the similarity ensemble approach (SEA) database predicted the antimalarial activity of each of these compounds, which were shown using an in vitro assay against Plasmodium falciparum. However, treatment of P. berghei-infected mice with 3 increased parasitemia levels and mortality, whereas treatment with 2 was protective, causing a parasitemia reduction and a delay in mortality in P. berghei-infected mice. The exacerbation of in vivo infection by treatment with 3 is probably due to its potent immunosuppressive activity, which is not evident for 2
DeCS: Antimaláricos/farmacologia
Imunossupressores/farmacologia
Physalis/química
Plasmodium berghei/efeitos de drogas
Plasmodium falciparum/efeitos de drogas
Secoesteroides/farmacologia
Animais
Antimaláricos/química
Antimaláricos/isolamento & purificação
Imunossupressores/química
Imunossupressores/isolamento & purificação
Malária/quimioterapia
Camundongos
Camundongos Endogâmicos BALB C
Parasitemia/quimioterapia
Secoesteroides/química
Secoesteroides/isolamento & purificação
Issue Date: 2011
Publisher: American Chemical Society and American Society of Pharmacognosy
Citation: SÁ, M. S. et al. Antimalarial activity of physalins B, D, F, and G. Journal of Natural Products, v. 74, n. 10, p. 2269-2272, 2011.
DOI: dx.doi.org/10.1021/np200260f |
ISSN: 1520-6025
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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