| Author | Soares, Bárbara Ribeiro | |
| Author | Souza, Ana Paula Almeida de | |
| Author | Prates, Deboraci Brito | |
| Author | Oliveira, Camila Indiani de | |
| Author | Barral Netto, Manoel | |
| Author | Miranda, José Carlos | |
| Author | Barral, Aldina Maria Prado | |
| Access date | 2014-02-21T13:30:10Z | |
| Available date | 2014-02-21T13:30:10Z | |
| Document date | 2013 | |
| Citation | SOARES, B. R. et al. Seroconversion of sentinel chickens as a biomarker for monitoring exposure to visceral leishmaniasis. Scientific Reports, v. 3, p. 2352, 2013. | pt_BR |
| ISSN | 2045-2322 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7343 | |
| Language | eng | pt_BR |
| Publisher | Nature | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Leishmania | pt_BR |
| Subject in Portuguese | Leishmania infantum | pt_BR |
| Subject in Portuguese | Leishmaniose visceral | pt_BR |
| Subject in Portuguese | Lutzomyia longipalpis | pt_BR |
| Subject in Portuguese | Psychodidae | pt_BR |
| Subject in Portuguese | Proteinas salivares | pt_BR |
| Subject in Portuguese | Saliva | pt_BR |
| Subject in Portuguese | Animais | pt_BR |
| Subject in Portuguese | Galinhas | pt_BR |
| Subject in Portuguese | Transmissao | pt_BR |
| Title | Seroconversion of sentinel chickens as a biomarker for monitoring exposure to visceral leishmaniasis | pt_BR |
| Type | Article | pt_BR |
| DOI | 0.1038/srep02352 | |
| Abstract | Leishmania infantum chagasi causes visceral leishmaniasis (VL); it is transmitted by the sand fly Lutzomyia longipalpis that injects saliva and parasites into the host's skin during a blood meal. Chickens represent an important blood source for sand flies and their presence in the endemic area is often cited as a risk factor for VL transmission. However, the role of chickens in VL epidemiology has not been well defined. Here, we tested if chicken antibodies against Lu. longipalpis salivary gland sonicate (SGS) could be used as markers of exposure to sand fly bites. All naturally exposed chickens in a VL endemic area in Brazil developed anti-SGS IgY antibodies. Interestingly, Lu. longipalpis recombinant salivary proteins rLJM17 and rLJM11 were also able to detect anti-SGS IgY antibodies. Taken together, these results show that chickens can be used to monitor the presence of Lu. longipalpis in the peri-domiciliary area in VL endemic regions, when used as sentinel animals. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biomorfologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia - INCT. Instituto de Investigação em Imunologia (iii). Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia - INCT. Instituto de Investigação em Imunologia (iii). Salvador, BA, Brasil | pt_BR |
