Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7343
Title: Seroconversion of sentinel chickens as a biomarker for monitoring exposure to visceral leishmaniasis
Authors: Soares, Bárbara Ribeiro
Souza, Ana Paula Almeida de
Prates, Deboraci Brito
Oliveira, Camila Indiani de
Barral Netto, Manoel
Miranda, José Carlos
Barral, Aldina Maria Prado
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biomorfologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia - INCT. Instituto de Investigação em Imunologia (iii). Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia - INCT. Instituto de Investigação em Imunologia (iii). Salvador, BA, Brasil
Abstract: Leishmania infantum chagasi causes visceral leishmaniasis (VL); it is transmitted by the sand fly Lutzomyia longipalpis that injects saliva and parasites into the host's skin during a blood meal. Chickens represent an important blood source for sand flies and their presence in the endemic area is often cited as a risk factor for VL transmission. However, the role of chickens in VL epidemiology has not been well defined. Here, we tested if chicken antibodies against Lu. longipalpis salivary gland sonicate (SGS) could be used as markers of exposure to sand fly bites. All naturally exposed chickens in a VL endemic area in Brazil developed anti-SGS IgY antibodies. Interestingly, Lu. longipalpis recombinant salivary proteins rLJM17 and rLJM11 were also able to detect anti-SGS IgY antibodies. Taken together, these results show that chickens can be used to monitor the presence of Lu. longipalpis in the peri-domiciliary area in VL endemic regions, when used as sentinel animals.
keywords: Leishmania
Leishmania infantum
Leishmaniose visceral
Lutzomyia longipalpis
Psychodidae
Proteinas salivares
Saliva
Animais
Galinhas
Transmissao
Issue Date: 2013
Publisher: Nature
Citation: SOARES, B. R. et al. Seroconversion of sentinel chickens as a biomarker for monitoring exposure to visceral leishmaniasis. Scientific Reports, v. 3, p. 2352, 2013.
DOI: 0.1038/srep02352
ISSN: 2045-2322
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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