Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7355
Title: Biomarkers for susceptibility to infection and disease severity in human malaria
Authors: Andrade, Bruno de Bezerril
Barral Netto, Manoel
Affilliation: National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USA
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia. Salvador, BA, Brasil
Abstract: Malaria remains a major infectious disease that affects millions of people. Once infected with Plasmodium parasites, a host can develop a broad range of clinical presentations, which result from complex interactions between factors derived from the host, the parasite and the environment. Intense research has focused on the identification of reliable predictors for exposure, susceptibility to infection and the development of severe complications during malaria. Although most promising markers are based on the current understanding of malaria immunopathogenesis, some are also focused more broadly on mechanisms of tissue damage and inflammation. Taken together, these markers can help optimise therapeutic strategies and reduce disease burden. Here, we review the recent advances in the identification of malarial biomarkers, focusing on those related to parasite exposure and disease susceptibility. We also discuss priorities for research in biomarkers for severe malaria.
Keywords: Malaria
Plasmodium
Biomarker
Inflammation
DeCS: Marcadores Biológicos/análise
Malária Falciparum/transmissão
Malária Vivax/transmissão
Animais
Anopheles/parasitologia
Suscetibilidade a Doenças
Humanos
Insetos Vetores/parasitologia
Malária Falciparum/genética
Malária Falciparum/imunologia
Malária Vivax/genética
Malária Vivax/imunologia
Plasmodium falciparum/imunologia
Plasmodium falciparum/fisiologia
Plasmodium vivax/imunologia
Plasmodium vivax/fisiologia
Índice de Gravidade de Doença
Issue Date: 2011
Publisher: Instituto Oswaldo Cruz
Citation: ANDRADE, B. B.; BARRAL-NETTO, M. Biomarkers for susceptibility to infection and disease severity in human malaria. Memórias do Instituto Oswaldo Cruz, v. 106, suppl. I, p. 70-78, 2011.
ISSN: 1678-8060
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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