Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7377
Title: Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance
Authors: Andrade, Bruno de Bezerril
Reis Filho, Antonio José Souza
Souza Neto, Sebastião Martins
Clarêncio, Jorge
Camargo, Luís Marcelo Aranha
Barral, Aldina Maria Prado
Barral Netto, Manoel
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Universidade de São Paulo. Instituto de Ciências Biológicas. Departamento de Parasitologia. São Paulo, SP, Brasil / Faculdade de Medicina. Faculdade São Lucas. Rondônia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia (INCT). Instituto de Investigação em Imunologia (iii). São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia (INCT). Instituto de Investigação em Imunologia (iii). São Paulo, SP, Brasil
Abstract: Despite clinical descriptions of severe vivax malaria cases having been reported, data regarding immunological and inflammatory patterns are scarce. In this report, the inflammatory and immunological status of both mild and severe vivax malaria cases are compared in order to explore immunopathological events in this disease. METHODS AND RESULTS: Active and passive malaria case detections were performed during 2007 in Buritis, Rondônia, in the Brazilian Amazon. A total of 219 participants enrolled the study. Study individuals were classified according to the presence of Plasmodium vivax infection within four groups: non-infected (n = 90), asymptomatic (n = 60), mild (n = 50) and severe vivax infection (n = 19). A diagnosis of malaria was made by microscopy and molecular assays. Since at present no clear criteria define severe vivax malaria, this study adapted the consensual criteria from falciparum malaria. Patients with severe P. vivax infection were younger, had lived for shorter time in the endemic area, and recalled having experienced less previous malaria episodes than individuals with no malaria infection and with mild or asymptomatic infection. Strong linear trends were identified regarding increasing plasma levels of C reactive protein (CRP), serum creatinine, bilirubins and the graduation of disease severity. Plasma levels of tumour necrosis factor (TNF), interferon-gamma(IFN-gamma) and also IFN-gamma/interleukin-10 ratios were increased and exhibited a linear trend with gradual augmentation of disease severity. Both laboratory parameters of organ dysfunction and inflammatory cytokines were reduced during anti-parasite therapy in those patients with severe disease. CONCLUSION: Different clinical presentations of vivax malaria infection present strong association with activation of pro-inflammatory responses and cytokine imbalance. These findings are of utmost importance to improve current knowledge about physiopathological concepts of this serious widespread disease.
DeCS: Citocinas/sangue
Inflamação/imunologia
Malária Vivax/imunologia
Plasmodium vivax/isolamento & purificação
Adolescente
Adulto
Fatores etários
Idoso
Antimaláricos/uso terapêutico
Citocinas/imunologia
Citocinas/metabolismo
Citometria de Fluxo
Feminino
Inflamação/quimioterapia
Humanos
Malária Vivax/diagnóstico
Malária Vivax/quimioterapia
Masculino
Meia-Idade
Plasmodium vivax/imunologia
Reação em Cadeia da Polimerase
Índice de Gravidade de Doença
Adulto Jovem
Issue Date: 2010
Publisher: BioMed Central Ltd
Citation: ANDRADE, B. B. et al. Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance. Malaria Journal, v. 9, p.13-20, 2010.
ISSN: 1475-2875
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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