| Autor | Brocco, Marcos Célio | |
| Autor | Paulo, Danilo Nagib Salomão | |
| Autor | Almeida, Carlos Eduardo David de | |
| Autor | Carraretto, Antonio Roberto | |
| Autor | Cabral, Sigmar Aurea | |
| Autor | Silveira, Amanda Cardoso de Oliveira | |
| Autor | Gomez, Renato Santiago | |
| Autor | Baptista, João Florêncio de Abreu | |
| Data de acesso | 2014-03-07T13:02:58Z | |
| Data de disponibilização | 2014-03-07T13:02:58Z | |
| Data do publicação | 2012 | |
| Citação | BROCCO, Marcos Célio et al. A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine. Acta Cirúrgica Brasileira. 2012, vol.27, n.7, pp. 494-498 | pt_BR |
| ISSN | 0102-8650 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7380 | |
| Idioma | por | pt_BR |
| Editor | Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia. | pt_BR |
| Direito Autoral | open access | pt_BR |
| Título | A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine | pt_BR |
| Tipo do documento | Article | pt_BR |
| Resumo em Inglês | PURPOSE: The objective of this study was to assess the cytokine serum levels of IL-6 and TNF-α in rats subjected to fecal peritonitis and treated with peritoneal lavage with 0.2% ropivacaine by peritoneal lavage.
METHODS: We subjected 16 Wistar rats to laparotomy 6 hours after the induction of fecal peritonitis with autogenous stool and subsequently divided the rats randomly into 4 groups: I-control, no treatment; II- drying of the abdominal cavity; III- lavage of the abdominal cavity with 3 mL of 0.9% normal saline and drying; IV- lavage of the abdominal cavity with 3 mL of 0.2% ropivacaine and drying. Six hours following the laparotomy, the animals underwent cardiac puncture, and 1 mL of blood was collected for cytokine assessment before the animals were euthanized.
RESULTS: The lavage with ropivacaine resulted in smaller TNF-α levels compared with those observed in the other treatment groups (p <0.05). Regarding IL-6, the ropivacaine group showed lower cytokine levels than those observed in groups I and II, but there was no significant difference (p> 0.05) between groups III and IV.
CONCLUSION: Peritoneal lavage with 0.2% ropivacaine was shown to reduce plasma levels of IL-6 and TNF-α in the treatment of fecal peritonitis in rats | pt_BR |
| Afiliação | Espirito Santo Federal University Department of Surgery. Division of Anesthesiology. Vitória, ES, Brazil. | pt_BR |
| Afiliação | EMESCAM. Vitória, ES, Brazil. | pt_BR |
| Afiliação | Universidade Federal de Minas Gerais. Surgical and Ophthalmological Applied Sciences Postgraduate Program. Belo Horizonte, MG, Brazil. | pt_BR |
| Afiliação | Espirito Santo Federal University. Department of Surgery. Division of Anesthesiology. Vitória, ES, Brazil. | pt_BR |
| Afiliação | Universidade Federal de Minas Gerais. Surgical and Ophthalmological Applied Sciences Postgraduate Program. Belo Horizonte, MG, Brazil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratory analysis and Interpretation of data. | pt_BR |
| Afiliação | Minas Gerais Federal University. Department of Surgery. Belo Horizonte, MG, Brazil | pt_BR |
| Afiliação | Espirito Santo Federal University. Department of Surgery. Division of Anesthesiology. Vitória, ES, Brazil | pt_BR |
| Palavras-chave em inglês | Peritonitis | pt_BR |
| Palavras-chave em inglês | Anesthesia | pt_BR |
| Palavras-chave em inglês | Sepsis | pt_BR |
| Palavras-chave em inglês | IL-6 | pt_BR |
