Author | Oliveira, Camila Indiani de | |
Author | Nascimento, Ivan Pereira | |
Author | Barral, Aldina Maria Prado | |
Author | Soto, Manuel | |
Author | Barral Netto, Manoel | |
Access date | 2014-03-13T13:32:09Z | |
Available date | 2014-03-13T13:32:09Z | |
Document date | 2009 | |
Citation | OLIVEIRA, C. I. de et al. Challenges and perspectives in vaccination against leishmaniasis. Parasitology International, v. 58, p. 319–324, 2009. | pt_BR |
ISSN | 1873-0329 | |
URI | https://www.arca.fiocruz.br/handle/icict/7401 | |
Language | eng | pt_BR |
Publisher | Elsevier Ireland Ltd. | pt_BR |
Rights | open access | pt_BR |
Title | Challenges and perspectives in vaccination against leishmaniasis. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.parint.2009.07.013 | |
Abstract | The leishmaniases are a group of diseases caused by protozoa of the genus Leishmania and affect millions of people worldwide. The leishmaniases are transmitted to vertebrate hosts by phlebotomine sand flies. In this review, we focus on several issues that have been poorly addressed in ongoing efforts to develop a vaccine against Leishmania, namely: vaccination with antigens present in sand fly saliva, vaccines based on intracellular Leishmania antigens, and use of recombinant BCG as a vehicle for vaccination. Additionally, we address the differences between L. major and L. braziliensis and the impact that these differences may have on strategies for immunoprophylaxis | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidad Autónoma de Madrid. Facultad de Ciencias. Centro de Biología Molecular Severo Ochoa. Departamento de Biología Molecular. Madrid, Spain | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Salvador, BA, Brasil | pt_BR |
Subject | Leishmania | pt_BR |
Subject | Sandy fly | pt_BR |
Subject | Saliva | pt_BR |
Subject | BCG | pt_BR |
DeCS | Leishmania braziliensis/imunologia | pt_BR |
DeCS | Leishmania major/imunologia | pt_BR |
DeCS | Leishmaniose Cutânea/prevenção & controle | pt_BR |
DeCS | Vacinas Protozoárias | pt_BR |
DeCS | Psychodidae | pt_BR |
DeCS | Saliva | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Antígenos de Protozoários/genética | pt_BR |
DeCS | Antígenos de Protozoários/imunologia | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Leishmaniose Cutânea/parasitologia | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Mycobacterium bovis/genética | pt_BR |
DeCS | Vacinas Protozoárias/administração & dosagem | pt_BR |
DeCS | Vacinas Protozoárias/imunologia | pt_BR |
DeCS | Psychodidae/imunologia | pt_BR |
DeCS | Psychodidae/parasitologia | pt_BR |
DeCS | Saliva/imunologia | pt_BR |
DeCS | Saliva/parasitologia | pt_BR |
DeCS | Vacinação | pt_BR |