Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7401
Title: Challenges and perspectives in vaccination against leishmaniasis.
Authors: Oliveira, Camila Indiani de
Nascimento, Ivan Pereira
Barral, Aldina Maria Prado
Soto, Manuel
Barral Netto, Manoel
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Salvador, BA, Brasil
Universidad Autónoma de Madrid. Facultad de Ciencias. Centro de Biología Molecular Severo Ochoa. Departamento de Biología Molecular. Madrid, Spain
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Salvador, BA, Brasil
Abstract: The leishmaniases are a group of diseases caused by protozoa of the genus Leishmania and affect millions of people worldwide. The leishmaniases are transmitted to vertebrate hosts by phlebotomine sand flies. In this review, we focus on several issues that have been poorly addressed in ongoing efforts to develop a vaccine against Leishmania, namely: vaccination with antigens present in sand fly saliva, vaccines based on intracellular Leishmania antigens, and use of recombinant BCG as a vehicle for vaccination. Additionally, we address the differences between L. major and L. braziliensis and the impact that these differences may have on strategies for immunoprophylaxis
Keywords: Leishmania
Sandy fly
Saliva
BCG
DeCS: Leishmania braziliensis/imunologia
Leishmania major/imunologia
Leishmaniose Cutânea/prevenção & controle
Vacinas Protozoárias
Psychodidae
Saliva
Animais
Antígenos de Protozoários/genética
Antígenos de Protozoários/imunologia
Animais
Leishmaniose Cutânea/parasitologia
Camundongos
Mycobacterium bovis/genética
Vacinas Protozoárias/administração & dosagem
Vacinas Protozoárias/imunologia
Psychodidae/imunologia
Psychodidae/parasitologia
Saliva/imunologia
Saliva/parasitologia
Vacinação
Issue Date: 2009
Publisher: Elsevier Ireland Ltd.
Citation: OLIVEIRA, C. I. de et al. Challenges and perspectives in vaccination against leishmaniasis. Parasitology International, v. 58, p. 319–324, 2009.
DOI: 10.1016/j.parint.2009.07.013
ISSN: 1873-0329
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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