Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7410
Title: Role of sand fly saliva in human and experimental leishmaniasis: current insights.
Authors: Andrade, Bruno de Bezerril
Oliveira, Camila Indiani de
Brodskyn, Claudia Ida
Barral, Aldina Maria Prado
Barral Netto, Manoel
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Instituto do Milênio. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Instituto do Milênio. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Instituto do Milênio. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Instituto do Milênio. Salvador, BA, Brasil
Abstract: Leishmaniases are wide spread diseases transmitted to their vertebrate host by infected sand fly. The saliva from these arthropods contains a vast repertoire of pharmacologically active molecules that hampers the host’s haemostatic, inflammatory and immune responses. The early interactions between Leishmania and the host’s immune response are closely linked to disease evolution or protection against the protozoan, and the ectoparasite saliva contributes directly to these interactions. Current studies have depicted these features, and these relations are being widely explored. There are concrete indications that the host response against sand fly saliva influences disease outcome in leishmaniasis. Additionally, there are demonstrations that immunization with whole sand fly saliva, or its components, leads to protection against leishmaniasis in different host species. The combination of these evidences opens up optimistic perspectives for improving vaccine development against Leishmania infection.
DeCS: Leishmania/crescimento & desenvolvimento
Leishmania/imunologia
Leishmaniose/imunologia
Leishmaniose/parasitologia
Psychodidae/imunologia
Psychodidae/parasitologia
Saliva/imunologia
Saliva/parasitologia
Animais
Modelos Animais de Doenças
Humanos
Issue Date: 2007
Publisher: Blackwell Publishing Ltd
Citation: ANDRADE, B. B. et al. Role of sand fly saliva in human and experimental leishmaniasis: current insights. Scandinavian Journal of Immunology, v. 66, n. 2-3, p. 122–127, 2007.
DOI: 10.1111/j.1365-3083.2007.01964.x
ISSN: 0300-9475
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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