Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7411
Title: Cellular analysis of cutaneous leishmaniasis lymphadenopathy: insights into the early phases of human disease.
Authors: Arruda, Maria da Gloria Bomfim
Andrade, Bruno de Bezerril
Santos, Silvane
Clarêncio, Jorge
Barral Netto, Manoel
Barral, Aldina Maria Prado
Affilliation: Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Instituto do Milênio. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Instituto do Milênio. Salvador, BA, Brasil
Abstract: Lymphadenopathy is an early clinical sign in cutaneous leishmaniasis (CL), caused by Viannia parasites, and may help to understand the initial host response to these species of Leishmania. We report on characteristics of cells obtained from lymph nodes from cutaneous leishmaniasis patients with lymphadenopathy without ulceration (early phase, N = 21) or lymphadenopathy and ulceration (late phase, N = 29). Early-phase patients exhibited a higher proportion of neutrophils, eosinophils, and CD8+ T cells. Conversely, CD19+ B lymphocytes and plasma cells were more frequently observed in late-phase patients. The signal for IL-10 was significantly higher in late-phase patients; signals for IFN-gamma or IL-4 were similar in both groups. These data reinforce observations of an initial mixed Th1-Th2 profile as well as the early role of the CD8 T cell in cutaneous leishmaniasis. Additionally, there is a chronologic relationship between ulcer development and B-cell increase. IL-10 also increases at a late stage and may be important in limiting tissue damage.
DeCS: Leishmaniose Cutânea/patologia
Linfonodos/citologia
Doenças Linfáticas/patologia
Adolescente
Adulto
Crianças
Humanos
Feminino
Masculino
Meia-Idade
Pele/patologia
Issue Date: 2007
Publisher: The American Society of Tropical Medicine and Hygiene
Citation: BOMFIM, G. et al. Cellular analysis of cutaneous leishmaniasis lymphadenopathy: insights into the early phases of human disease. American Journal of Tropical Medicine Hygiene, v. 77, n. 5, p. 854–859, 2007.
ISSN: 1476-1645
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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