Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7433
Title: Vaccines in leishmaniasis: advances in the last five years
Authors: Brodskyn, Claudia Ida
Oliveira, Camila Indiani de
Barral, Aldina Maria Prado
Barral Netto, Manoel
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoregulação. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoregulação. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoregulação. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoregulação. Salvador, BA, Brasil
Abstract: The leishmaniases are a group of diseases caused by protozoa of the genus Leishmania which affects millions of people worldwide. The leishmaniases are transmitted to the vertebrate hosts by phlebotomine sand flies. In this review, we focus on clinical aspects of the leishmaniases and on the immune response against the parasite, both in animal models and humans. These aspects are of key importance to understand the many attempts to obtain an effective vaccine against Leishmania. We considered the last advances in new generation vaccines, including the use of new adjuvants to improve the protective response against the parasite. Finally, the possibility to use components of the sand fly saliva as part of vaccines against the infection by Leishmania is mentioned
Keywords: Co stimulatory molecules
Cytokines
Immunoregulation
IVP
Leishmania
Leishmaniasis
Sandy fly
Vaccine
DeCS: Leishmaniose Cutânea/prevenção & controle
Leishmaniose Visceral/prevenção & controle
Vacinas Protozoárias/imunologia
Animais
Antiprotozoários/uso terapêutico
Humanos
Leishmania/imunologia
Leishmania/patogenicidade
Leishmaniose Cutânea/quimioterapia
Leishmaniose Cutânea/parasitologia
Leishmaniose Visceral/quimioterapia
Leishmaniose Visceral/parasitologia
Vacinas Protozoárias/administração & dosagem
Issue Date: 2003
Publisher: Future Drugs LTD
Citation: BRODSKYN C. et al. Vaccines in leishmaniasis: advances in the last five years. Expert Review of Vaccines, v.2, n.5, p. 705-717, 2003.
ISSN: 1476-0584
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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