Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7443
Title: Immunochemotherapy with interferon-gamma and multidrug therapy for multibacillary leprosy.
Authors: Barral Netto, Manoel
Santos, S
Santos, Isis Fernandes Magalhães
Von Sohsten, R. L
Bittencourt, Achilea Candida Lisboa
Carvalho Filho, Edgar Marcelino
Barral, Aldina Maria Prado
Waters, M
Affilliation: Universidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil
Universidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. HUPES. Serviço de Anatomia Patológica. SAlvador, BA, Brasil
Universidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, Brasil
Hospital for Tropical Diseases, London, UK
Abstract: Treatment for multibacillary leprosy is presently performed with a multidrug therapy (MDT) scheme maintained for 2 years. Leprosy treatment however can benefit from the reduction of length. The lack of interferon-gamma (IFN-gamma) production by lepromatous leprosy (LL) patients' lymphocytes lead us to use this cytokine in the treatment of multibacillary leprosy associated with MDT in the treatment of multibacillary leprosy, and monitor several clinical and immunological parameters during the course of treatment. A total of 20 multibacillary leprosy patients were evaluated, 10 treated with MDT alone, and 10 treated with MDT + 10 daily doses of 2 x 10(6) international units (IU) of recombinant human IFN-gamma/m2 followed by 10 daily doses of 10(7) IU IFN-gamma/m2, intramuscularly, during the first 20 days of MDT. IFN-gamma was well tolerated and did not cause any increase in the rate of leprosy reactions development during treatment. Decrease of bacillary load, fall of anti-Mycobacterium leprae IgG serum antibodies, changes of histological pattern, as well as changes in lymphocyte proliferation assay in response to mitogens (PHA or PWM), M. leprae antigen or PPD was similar in both groups of patients. Among several soluble immunological markers measured before and 30 days after beginning of treatment, levels of soluble IL-2R receptor increased in patients treated with MDT plus IFN-gamma whereas decreased in patients treated with MDT alone. Soluble ICAM-1 levels decreased in the MDT group but did not change in the MDT + IFN-gamma treated patients. Soluble CD4 and soluble CD8 markers did not change significantly in either group of patients. Neopterin, a marker of macrophage activation, increased in all but one patient treated with MDT + IFN-gamma but in none treated with MDT alone, indicating that IFN-gamma was active in vivo. Our findings indicate that despite being able to promote macrophage activation in multibacillary leprosy patients a short course of systemically administered IFN-gamma is not able to change the clinical course of a long standing disease such as leprosy.
DeCS: Interferon gama/uso terapêutico
Hansenostáticos/uso terapêutico
Hanseníase/quimioterapia
Anticorpos Antibacterianos/sangue
Adolescente
Adulto
Criança
Clofazimina/uso terapêutico
Dapsona/uso terapêutico
Quimioterapia Combinada
Feminino
Humanos
Interferon gama/biossíntese
Hanseníase/imunologia
Ativação Linfocitária
Meia-Idade
Masculino
Neopterina/análise
Proteínas Recombinantes
Rifampina/uso terapêutico
Pele/microbiologia
Issue Date: 1999
Publisher: Elsevier B.V
Citation: BARRAL-NETTO, M. et al. Immunochemotherapy with interferon-gamma and multidrug therapy for multibacillary leprosy. Acta Tropica, v. 72, n. 2, p. 185-201, 1999.
ISSN: 0001-706X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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