Author | Barral Netto, Manoel | |
Author | Von Sohsten, R. L | |
Author | Teixeira, M | |
Author | dosSantos, Washington Luis Conrado | |
Author | Pompeu, Margarida Maria de Lima | |
Author | Moreira, R. A | |
Author | Oliveira, J. T | |
Author | Cavada, Benildo Sousa | |
Author | Falcoff, E | |
Author | Barral, Aldina Maria Prado | |
Access date | 2014-03-26T16:41:14Z | |
Available date | 2014-03-26T16:41:14Z | |
Document date | 1996 | |
Citation | BARRAL-NETTO, M. et al. In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis. Acta Tropica, v. 60, n. 4, p. 237-250 237, 1996. | pt_BR |
ISSN | 0001-706X | |
URI | https://www.arca.fiocruz.br/handle/icict/7452 | |
Language | eng | pt_BR |
Publisher | Elsevier Science B.V | pt_BR |
Rights | open access | pt_BR |
Title | In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis | pt_BR |
Type | Article | pt_BR |
Abstract | In vivo administration of Canavalia brasiliensis lectin (at the time of infection, or maintained throughout the infection) reduced the lesions of highly susceptible BALB/c mice infected by Leishmania amazonensis. At the doses used C. brasiliensis lectin (ConBr) does not interfere with penetration or fate of Leishmania in the macrophages in vitro. Since Interferon-gamma (IFN-gamma) is the major macrophage activating factor, and considered a critical element in the successful immune response against leishmaniasis, we explored its participation in this phenomenon. ConBr either in vivo or in vitro induced IFN-gamma production in normal or in leishmania-infected BALB/c mice. However we were unable to change the course of disease by in vivo IFN-gamma administration (although IFN-gamma preparations were effective in inducing a leishmanicidal effect in vitro on L. amazonensis-infected peritoneal macrophages). Additionally, IFN-gamma neutralization with anti-IFN-gamma monoclonal antibody did not alter the protection conferred by ConBr administration. These data show that lectin administration in vivo is protective in the otherwise unchecked L. amazonensis infection of BALB/c mice, and suggest that such effect is not mediated by IFN-gamma. | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Univ. Prof. Edgard Santos. Serviço de lmunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / LAboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Univ. Prof. Edgard Santos. Serviço de lmunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Univ. Prof. Edgard Santos. Serviço de lmunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Univ. Prof. Edgard Santos. Serviço de lmunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal do Ceará. Departamentos de Patologia & Bioquimica. Fortaleza, CE, Brasil | pt_BR |
Affilliation | Universidade Federal do Ceará. Departamentos de Patologia & Bioquimica. Fortaleza, CE, Brasil | pt_BR |
Affilliation | Universidade Federal do Ceará. Departamentos de Patologia & Bioquimica. Fortaleza, CE, Brasil | pt_BR |
Affilliation | Universidade Federal do Ceará. Departamentos de Patologia & Bioquimica. Fortaleza, CE, Brasil | pt_BR |
Affilliation | lnstitut Curie. Unitk INSERM. PAris, France | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Univ. Prof. Edgard Santos. Serviço de lmunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Leishmaniasis | pt_BR |
Subject | Leishmania | pt_BR |
Subject | Tegumentary leishmaniasis | pt_BR |
Subject | Experimental leishmaniasis | pt_BR |
Subject | Canavalia brasiliensis | pt_BR |
Subject | Interferon-y | pt_BR |
Subject | Animais | pt_BR |
Subject | Feminino | pt_BR |
DeCS | Interferon gama/biossíntese | pt_BR |
DeCS | Lectinas/uso terapêutico | pt_BR |
DeCS | Leishmania mexicana | pt_BR |
DeCS | Leishmaniose Cutânea/terapia | pt_BR |
DeCS | Interferon gama/farmacocinética | pt_BR |
DeCS | Leishmaniose Cutânea/imunologia | pt_BR |
DeCS | Leishmaniose Cutânea/parasitologia | pt_BR |
DeCS | Macrófagos Peritoneais/efeitos de drogas | pt_BR |
DeCS | Macrófagos Peritoneais/parasitologia | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Camundongos Endogâmicos BALB C | pt_BR |
DeCS | Ratos | pt_BR |