Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7466
Title: Interleukin-2 production during murine infection by Leishmania mexicana amazonensis.
Authors: Barral Netto, Manoel
Roters, Silene B.
Barral, Aldina Maria Prado
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Prof. Edgar Santos. Laboratório de Imunologia. Salvador, BA, Brasil
Abstract: Highly susceptible BALB/c mice, resistant C57B1/6 and their F1 progeny (BDF1) were infected subcutaneously in the foot pad with Leishmania mexicana amazonensis. At various times after infection, spleen or draining popliteal lymph node cells were assayed for their capacity to generate Interleukin-2 (I1-2) by Concanavalin A (ConA) stimulation. In both BALB/c and C57B1/6 strains there was a transient increase in their capacity to produce I1-2, from the 3rd to the 10th week post-infection. Return to pre-infection levels occurred between 13th to 16th week post-infection in all three strains. BALB/c mice always produced higher titers of I1-2 than C57B1/6, but such differences were statistically significant only at 3 and 10 weeks post-infection. BDF1 mice had titers similar to those observed in BALB/c mice. I1-2 production by ConA-stimulated lymph node cells was lower as compared to the spleen, but with a similar pattern among the three mice strains. Our data show that susceptibility to infection by L. mexicana amazonensis is not associated with deficient ConA-stimulated I1-2 production.
Keywords: Cutaneous leishmaniasis
Interleukin-2
Leishmania (immunology)
Murine leishmaniasis
Lymphokines
DeCS: Concanavalina A/farmacologia
Interleucina-2/biossíntese
Leishmaniose/imunologia
Baço/imunologia
Animais
Leishmania mexicana/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
Issue Date: 1986
Publisher: Fiocruz
Citation: BARRAL-NETTO, M.; ROTERS, S. B.; BARRAL, A. Interleukin-2 production during murine infection by Leishmania mexicana amazonensis. Memórias do Instituto Oswaldo Cruz, v. 81, n. 1, p. 43-47, 1986.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos

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