Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7503
Title: Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes.
Authors: Santos, Cleiton Silva
Macedo, Júlio Oliveira
Bandeira, Maurício
Chagas Júnior, Adenizar Delgado das
McBride, Alan John Alexander
McBride, Flávia Weykamp da Cruz
Reis, Mitermayer Galvão dos
Athanazio, Daniel Abensur
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Salvador, BA, Brasil
Federal University of Bahia. Salvador, BA, Brasil
Abstract: The mouse disease model has the advantage of a broad array of immunological and genetic tools available for basic research. Some studies on transgenic and/or mutant mouse strains as models for experimental leptospirosis have been reported; however, the wider use of such models is hampered by a poor understanding of the outcome of experimental leptospiral infection among the different mouse strains available. Here, the outcome of infection by a virulent strain of Leptospira interrogans serogroup Icterohaemorrhagiae strain Cop was studied in four commonly used wildtype mouse strains: A, CBA, BALB/c and C57BL/6. The end points evaluated in this study were survival, presence of kidney lesions, leptospiral load in kidney samples, microscopic agglutination test titre and anti-leptospiral IgG antibody levels. As expected, none of the mouse strains were susceptible to lethal leptospirosis. However, these strains developed specific pathologies associated with sublethal leptospirosis. The A and C57BL/6 strains exhibited a high leptospiral load in kidney samples and the CBA and C57BL/6 strains developed severe inflammatory lesions, whilst the BALB/c strain proved to be the most resistant to subclinical leptospirosis
DeCS: Predisposição Genética para Doença
Genótipo
Leptospirose/genética
Animais
Leptospira interrogans
Leptospirose/imunologia
Camundongos
Camundongos Endogâmicos
Issue Date: 2010
Publisher: SGM
Citation: SANTOS, C. S. et al. Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes. Journal of Medical Microbiology, v. 59, n. 9, p. 1101–1106, 2010.
ISSN: 1473-5644
10.1099/jmm.0.021089-0
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos

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