Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7518
Title: Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil.
Authors: Machado Junior, Almério
Finkmoore, Brook
Emodi, Krisztina
Takenami, Iukary Oliveira
Bessa, Theolis Costa Barbosa
Tavares, Maria Brandão
Reis, Mitermayer Galvão dos
Arruda, Sérgio Marcos
Riley, Lee Woodland
Affilliation: Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Especializado Octávio Mangabeira. Salvador, BA, Brasil
University of California. Berkeley School of Public Health. California, USA
University of California. Berkeley School of Public Health. California, USA
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública, Centro de Pesquisas Gonçalo Moniz, Salvador, BA, BraSil
University of California. Berkeley School of Public Health. California, USA
Abstract: BACKGROUND: Although treatment of latent tuberculosis infection (LTBI) is an essential component of tuberculosis (TB) control in countries such as the United States, it is not widely practiced in most TB-endemic countries. OBJECTIVE: To examine the practice of and adherence to LTBI treatment in a high-risk population in Brazil. DESIGN: We followed household contacts (HHCs) of patients hospitalized with pulmonary TB in Salvador, Brazil, for 6 months after they initiated LTBI treatment with isoniazid (INH). HHCs were asked to return to the hospital once a month for 6 months for follow-up visits and INH refills. RESULTS: Of 101 HHCs who initiated LTBI treatment, 54 (53.5%) completed the 6-month regimen. The risk of treatment non-completion was significantly higher in HHCs who reported side effects to INH (RR 2.69, 95%CI 1.3-5.8, P = 0.01), and in those who had to take two buses for a one-way trip to the hospital (RR 1.8, 95%CI 1.01-3.3, P = 0.04). Of the 101 HHCs, 29 (28.7%) did not return for any follow-up visits; these HHCs were significantly more likely to have a 2-bus commute to the hospital compared to HHCs who completed treatment (OR 20.69, 95%CI 2.1-208.4, P = 0.01). CONCLUSION: Nearly 50% of HHCs at high risk for developing TB completed a 6-month course of LTBI treatment. Completion of LTBI treatment was most affected by medication intolerance and commuting difficulties for follow-up visits.
Keywords: Latent tuberculosis infection
Isoniazid
Adherence
hoUsehold contacts
DeCS: Antituberculosos/uso terapêutico
Isoniazida/uso terapêutico
Adesão à Medicação
Tuberculose Pulmonar/quimioterapia
Adolescente
Adulto
Brasil
Criança
Pré-Escolar
Feminino
Seguimentos
Humanos
Lactente
Recém-Nascido
Masculino
Estudos Prospectivos
Fatores de Risco
Transportes
Adulto Jovem
Issue Date: 2009
Publisher: The Union
Citation: MACHADO JUNIOR, A. et al. Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil.The International Journal of Tuberculosis and Lung Disease, v. 13, n. 6, p. 719-725, 2009.
ISSN: 1027-3719
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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