Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7525
Title: Experimental infection in tumor necrosis factor alpha receptor, interferon gamma and interleukin 4 deficient mice by pathogenic Leptospira interrogans
Authors: Athanazio, Daniel Abensur
Santos, Cleiton Silva
Santos, Andréia Carvalho dos
McBride, Flávia Weykamp da Cruz
Reis, Mitermayer Galvão dos
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Abstract: Only recently, knockout mouse models were applied in studies on the pathogenesis of leptospirosis. Current data suggest an important role of innate immunity receptors and interferon gamma dependant cellular response on protection. It is not clear, however, whether T helper cell polarization influences on outcome of leptospiral infection. We report findings of experimental infection of C57BL/6 (interferon gamma or tumor necrosis factor alpha receptor deficient) and BALB/c (interleukin 4 deficient) mice infected by pathogenic Leptospira interrogans serovar Copenhageni. Specific cytokine gene deficiency had no impact on outcome since all animals survived. TNFR knockout mice, however, exhibited more severe residual renal inflammation during convalescence thus suggesting this cytokine is important in early control of infection, protecting kidneys from relevant pathology.
Keywords: Leptospirosis
Leptospira
Mice
Knockout
Cytokines
Animal disease models
DeCS: Interferon gama/deficiência
Interleucina-4/deficiência
Leptospira interrogans/imunologia
Leptospirose/imunologia
Receptores do Fator de Necrose Tumoral/deficiência
Animais
Inflamação/patologia
Rim/patologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
Camundongos Knockout
Análise de Sobrevida
Issue Date: 2008
Publisher: Elsevier
Citation: ATHANAZIO, D. A. et al. Experimental infection in tumor necrosis factor alpha receptor, interferon gamma and interleukin 4 deficient mice by pathogenic Leptospira interrogans. Acta Tropica, v. 105, n. 1, p. 95-98, 2008.
DOI: 10.1016/j.actatropica.2007.09.004
ISSN: 0001-706X
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos

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