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GENETIC ANCESTRY AND INCOME ARE ASSOCIATED WITH DENGUE HEMORRHAGIC FEVER IN A HIGHLY ADMIXED POPULATION.
Blanton, Ronald Edward et al. | Date Issued: 2008
Author
Blanton, Ronald Edward
Silva, Luciano Kalabric
Morato, Vanessa G.
Parrado, Antonio R.
Dias, Juarez Pereira
Melo, Paulo Roberto Santana de
Reis, Eliana Almeida Gomes
Goddard, Katrina A. B.
Nunes, Márcio R. T.
Rodrigues, Sueli G.
Vasconcelos, Pedro F. C.
Castro, Jesuina M.
Reis, Mitermayer Galvão dos
Barreto, Maurício Lima
Teixeira, Maria da Glória
Affilliation
Case Western Reserve University. Center for Global Health and Diseases. Cleveland, OH, USA
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Universidade Federal da Bahia. Institute of Collective Health. Salvador, BA, Brasil
Case Western Reserve University. Division of Genetic Epidemiology. Department of Epidemiology & Biostatistics Wolstein Research Building. Cleveland, OH, USA
Secretaria da Saúde do Estado da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Case Western Reserve University. Division of Genetic Epidemiology. Department of Epidemiology & Biostatistics Wolstein Research Building. Cleveland, OH, USA
Instituto Evandro Chagas. Department of Arbovirology and Hemorrhagic Fever. Belém, PA, Brasil
Instituto Evandro Chagas. Department of Arbovirology and Hemorrhagic Fever. Belém, PA, Brasil
Instituto Evandro Chagas. Department of Arbovirology and Hemorrhagic Fever. Belém, PA, Brasil
Secretaria da Saúde do Estado da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Universidade Federal da Bahia. Institute of Collective Health. Salvador, BA, Brasil
Universidade Federal da Bahia. Institute of Collective Health. Salvador, BA, Brasil
Abstract
To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF (P¼0.02, OR¼0.28 and P¼0.02, OR¼0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF.
Keywords
Ethnicity
Race
Population structure
Socioeconomic status
DENV3
 
DeCS
Dengue/genética
Renda
Grupo com Ancestrais do Continente Africano/genética
Brasil
Genótipo
Humanos
 
Publisher
Nature Publishing Group
Citation
BLANTON, R. E. et al. Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. European Journal of Human Genetics, v. 16, n. 6, p. 762-765, 2008.
DOI
10.1038/ejhg.2008.4
ISSN
1018-4813