Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7547
Title: Anti-neutrophil cytoplasmic antibodies in leprosy.
Authors: Edington, Fernando Luiz Barros
Bacellar, Maria Olívia Amado Ramos
Machado, Paulo Roberto
Barbosa, Lúcio Macedo
Reis, Eliana Almeida Gomes
Reis, Mitermayer Galvão dos
Santiago, Mittermayer Barreto
Affilliation: Universidade Federal da Bahia. Salvador, BA, Brasil /
Universidade Federal da Bahia. Laboratório de Imunologia do Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil
Escola Baiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Federal da Bahia, Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Escola Baiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Santa Izabel. Serviço de Reumatologia. Salvador, BA, Brasil
Abstract: Introduction: Anti-Neutrophil Cytoplasmic Antibodies (ANCA) are auto-antibodies directed to intracellular components of neutrophils and used to be considered as present almost exclusively in granulomatous vasculitis. Recently, these auto-antibodies have been found in other autoimmune disorders as well as infectious diseases. Materials and methods: We studied patients with leprosy confirmed by bacilloscopy and/or skin biopsy, in reaction phase from the Ambulatório de Hanseníase do Hospital Universitário Professor Edgar Santos. ANCA and Antinuclear antibodies (ANA) were determined by indirect immunofluorescence using commercially available kits. Results: Twenty patients were enrolled in our study, nine males and 11 females. The mean age was 36.9± 18.2 years. ANCA were present only in one patient, with a perinuclear staining pattern (p-ANCA), and no patient tested positive for ANA. Discussion: Although other studies have shown the presence of ANCA in leprosy, the low frequency of these antibodies in leprosy sera demonstrated in the present study illustrates the high specificity of ANCA for the diagnosis of Wegener granulomatosis.
Keywords: Auto-antibodies
Hansen disease
Leprosy
Vasculitis
DeCS: Anticorpos Anticitoplasma de Neutrófilos/sangue
Hanseníase/imunologia
Adolescente
Adulto
Idoso
Biópsia
Criança
Feminino
Técnica Indireta de Fluorescência para Anticorpo
Humanos
Hanseníase/patologia
Masculino
Meia-Idade
Mycobacterium leprae/citologia
Mycobacterium leprae/isolamento & purificação
Kit de Reagentes para Diagnóstico
Pele/microbiologia
Pele/patologia
Issue Date: 2007
Publisher: Springer Verlag
Citation: EDINGTON, F. L. B. et al. Anti-neutrophil cytoplasmic antibodies in leprosy. Clinical Rheumatology, v. 26, n. 2, p. 208-210, 2007.
DOI: 10.1007/s10067-006-0281-7
ISSN: 0770-3198
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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