Author | Silva, Luciano Kalabric | |
Author | Silva, M. B. S. | |
Author | Rodart, Itatiana Ferreira | |
Author | Lopes, Gisele Barreto | |
Author | Costa, F. Q. | |
Author | Melo, M. E. | |
Author | Gusmão, E. | |
Author | Reis, Mitermayer Galvão dos | |
Access date | 2014-04-28T16:09:31Z | |
Available date | 2014-04-28T16:09:31Z | |
Document date | 2006 | |
Citation | SILVA, L. K. et al. Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil. Brazilian Journal of Medical and Biological Research, v. 39, n. 5, p. 595-602, 2006. | pt_BR |
ISSN | 0100-879X | |
URI | https://www.arca.fiocruz.br/handle/icict/7549 | |
Language | eng | pt_BR |
Publisher | Faculdade de Medicina de Ribeirao Preto Associacao Brasileira de Divulgacao | pt_BR |
Rights | open access | pt_BR |
Title | Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil | pt_BR |
Type | Article | pt_BR |
Abstract | Hepatitis C virus (HCV) infection has been identified as the major
cause of chronic liver disease among patients on chronic hemodialysis
(HD), despite the important reduction in risks obtained by testing
candidate blood donors for anti-HCV antibodies and the use of
recombinant erythropoietin to treat anemia. A cross-sectional study
was performed to estimate the prevalence of HCV infection and
genotypes among HD patients in Salvador, Northeastern Brazil. Anti-
HCV seroprevalence was determined by ELISA in 1243 HD patients
from all ten different dialysis centers of the city. HCV infection was
confirmed by RT-PCR and genotyping was performed by restriction
fragment length polymorphism. Anti-HCV seroprevalence among
HD patients was 10.5% (95% CI: 8.8-12.3) (Murex anti-HCV, Abbott
Murex, Chicago, IL, USA). Blood samples for qualitative HCV
detection and genotyping were collected from 125/130 seropositive
HD patients (96.2%). HCV-RNA was detected in 92/125 (73.6%) of
the anti-HCV-positive patients. HCV genotype 1 (77.9%) was the
most prevalent, followed by genotype 3 (10.5%) and genotype 2
(4.6%). Mixed infections of genotypes 1 and 3 were found in 7.0% of
the total number of patients. The present results indicate a significant
decrease in anti-HCV prevalence from 23.8% detected in a study
carried out in 1994 to 10.5% in the present study. The HCV genotype
distribution was closely similar to that observed in other hemodialysis
populations in Brazil, in local candidate blood donors and in other
groups at risk of transfusion-transmitted infection. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Departamento de Medicina Interna. Salvador, BA, Brasil | pt_BR |
Affilliation | 4Comissão Estadual de Nefrologia. Salvador, BA, Brasil | pt_BR |
Subject | Hepatitis C | pt_BR |
Subject | Seroprevalence | pt_BR |
Subject | Viremia | pt_BR |
Subject | Hemodialysis | pt_BR |
Subject | Genotype | pt_BR |
Subject | Brazil | pt_BR |
DeCS | Genótipo | pt_BR |
DeCS | Hepacivirus/genética | pt_BR |
DeCS | Anticorpos Anti-Hepatite C/sangue | pt_BR |
DeCS | Hepatite C/epidemiologia | pt_BR |
DeCS | Diálise Renal/efeitos adversos | pt_BR |
DeCS | Brasil/epidemiologia | pt_BR |
DeCS | Estudos Transversais | pt_BR |
DeCS | Eletroforese em Gel de Ágar | pt_BR |
DeCS | Ensaio de Imunoadsorção Enzimática | pt_BR |
DeCS | Hepacivirus/imunologia | pt_BR |
DeCS | Hepatite C/diagnóstico | pt_BR |
DeCS | Hepatite C/etiologia | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Reação em Cadeia da Polimerase | pt_BR |
DeCS | Polimorfismo de Fragmento de Restrição | pt_BR |
DeCS | Prevalência | pt_BR |
DeCS | RNA Viral/análise | pt_BR |
DeCS | Estudos Soroepidemiológicos | pt_BR |