Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7553
Title: Biochemical and immunologic predictors of efficacy of treatment or reinfection risk for Schistosoma mansoni.
Authors: Reis, Eliana Almeida Gomes
Reis, Mitermayer Galvão dos
Silva, Rita de Cássia Ribeiro
Carmo, Theomira Mauadie de Azevedo
Oliveira, Ana Marlucia de
Barreto, Maurício Lima
Parraga, Isabel Martin
Santana, Mônica Leila Portela de
Blanton, Ronald Edward
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia. School of Nutrition. Salvador, BA, BRasil
Institute of Collective Health. Federal University of Bahia. Salvador, BA, Brasil
Department of Nutrition. Case Western Reserve University. Cleveland, Ohio
School of Nutrition. Federal University of Bahia. Salvador, BA, Brasil
Center for Global Health and Diseases. Case Western Reserve University. Cornell Road. Building, Cleveland, Ohio
Abstract: Most Schistosoma mansoni infections are egg-negative after a single dose of oxamniquine. A cohort of 661 infected children was treated at 6-month intervals and assessed for nutritional and parasitological status. Initial biochemical and immunologic markers were measured in a subset of 84 children. All were treated at the start of therapy and at 6 months. Immunoglobulins only served as markers for active infection. No markers were predictive of cure or reinfection, except initial infection intensity and serum low-density lipoprotein. Ten percent were persistently infected and had no change in infection intensity at any time-point. Several factors suggest that this group was biologically different. In addition to failing to reduce their worm burden, they had significantly higher initial intensity of infection (100 versus 65 eggs/g, P 0.001) and significantly lower initial serum low-density lipoprotein (72 versus 104 mg/dL, P 0.045). The biologic plausibility of this observation is discussed.
DeCS: Valor Preditivo dos Testes
Recidiva
Schistosoma mansoni/imunologia
Esquistossomose mansoni/fisiopatologia
Adolescente
Animais
Criança
Estudos de Coortes
Feminino
Humanos
Masculino
Esquistossomose mansoni/quimioterapia
Esquistossomose mansoni/epidemiologia
Resultado do Tratamento
Issue Date: 2006
Publisher: The American Society of Tropical Medicine and Hygiene
Citation: REIS, E. A. et al. Biochemical and immunologic predictors of efficacy of treatment or reinfection risk for Schistosoma mansoni. American Journal of Tropical Medicine and Hygiene, v. 75, n. 5, p. 904-909, 2006.
ISSN: 0002-9637
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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