Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7571
Title: Hepatitis C virus genotypes in a northeastern area of Brazil.
Authors: Silva, Luciano Kalabric
Paraná, Raymundo
Souza, Sérgio P.
Kay, Alan
Trépo, Christian
Berby, Françoise
Santana, Nelma Pereira de
Cotrim, Helma Pinchemel
Lyra, Luiz Guilherme Costa
Reis, Mitermayer Galvão dos
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Hospital Universitário Professor Edgard Santos. ,Laboratório Gastroenterologia e Hepatologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Institut National de la Santé et de la Recherche Médicale Unité. Lyon, France
Institut National de la Santé et de la Recherche Médicale Unité. Lyon, France
Institut National de la Santé et de la Recherche Médicale Unité. Lyon, France
Hospital Universitário Professor Edgard Santos. ,Laboratório Gastroenterologia e Hepatologia. Salvador, BA, Brasil
Hospital Universitário Professor Edgard Santos. ,Laboratório Gastroenterologia e Hepatologia. Salvador, BA, Brasil
Hospital Universitário Professor Edgard Santos. ,Laboratório Gastroenterologia e Hepatologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Abstract: We used a reverse transcription-polymerase chain reaction (RT-PCR) to obtain the genotypes of circulating hepatitis C virus (HCV) in patients from a Gastro-Hepatology Unit in the city of Salvador (Bahia State) in northeastern Brazil. Viral RNA was detected in 83 (65.4%) of 127 anti-HCV seropositive serum samples. Positivity was significantly associated with alterations in levels of aspartate aminotransferase and alanine aminotransferase (P < 0.05). Genotyping of HCV was performed by RT-PCR using genotype-specific primers from the core region: 24.1% were infected with subtype 1a, 38.6% with 1b, 3.6% with 2, 21.7% with 3a, and 12.0% with a mixed genotype. There was no difference in genotype distribution when compared with results from other Brazilian locations. Surprisingly, the high frequency of genotype 3 in Brazilian samples continues to be different from that reported around the world and warrants further investigation
DeCS: Hepacivirus/genética
Hepatite C/virologia
Adolescente
Adulto
Idoso
Alanina Transaminase/sangue
Aspartato Aminotransferases/sangue
Southern Blotting
Brasil/epidemiologia
Primers do DNA/química
DNA Viral/química
Genótipo
Feminino
Hepacivirus/química
Hepatite C/epidemiologia
Técnicas Imunoenzimáticas
Humanos
Masculino
Meia-Idade
RNA Viral/química
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Estudos Soroepidemiológicos
Issue Date: 2000
Publisher: American Society of Tropical Medicine and Hygiene
Citation: SILVA, L. K. et al. Hepatitis C virus genotypes in a northeastern area of Brazil. American Journal of Tropical Medicine and Hygiene, v. 62, n. 2, p. 257-260, 2000.
ISSN: 0002-9637
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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