Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7616
Title: Up-regulation of T helper 2 and down-regulation of T helper 1 cytokines during murine retrovirus-induced immunodeficiency syndrome enhances susceptibility of a resistant mouse strain to Leishmania amazonensis
Authors: Barral Netto, Manoel
Silva, João Santana da
Barral, Aldina Maria Prado
Reed, Steven G
Affilliation: Federal University of Bahia. School of Medicine. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Ribeiro Preto University of São Paulo. Ribeirão Preto, SP, Brasil
Federal University of Bahia. School of Medicine. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Seattle Biomedical Research Institute. Seattle, Washington
Abstract: Resistance to and recovery from leishmania infection is dependent on cell-mediated immunity. C57BL/6 mice are resistant to Leishmania amazonensis (La) infection but susceptible to LP-BM5 murine leukemia virus (MuLV) infection. MuLVinfection leads to a state ofimmunodeficiency characterized by severe compromise ofcell-mediated immunity. When infected with La alone, C57BL/6 mice developed a smaU transient lesion that evolved to spontaneous healing or a lesion with extremely slow growth. Lesions were predominantly comprised ofa lympho-macrophagic infiltrate with few parasitized macrophages. When infected with La and, 4 weeks later, with MuLV (La-MuLV), the mice developed a large uncontrolled nonhealing lesion containing vacuolated and heavily parasitized macrophages. In contrast, mice infected with MuLV first and La 4 weeks later (MuLV-La) developed a smaU butpersistent lesion, characterized histologicaly by a smaU number of heavily parasitized macrophages andfew lympbocytes. Eight weeks after MuLV infection, both had similar immunological profiles with decreased lymphocyte proliferation, diminished production ofinterferon-)y, and high production of interleukins 4 and 10. At the time of L. amazonensis infection, La-MuLV animals have a normal T ceU function whereas in MuLV-La mice this function is already impaired,- this may influence the recruitment of macrophages to the site of leishmania injection.
keywords: Leishmania
Citocinas
Macrófagos
Retrovírus
Infecção
Animais
Ratos
Camundongos
Issue Date: 1995
Publisher: American Association of Pathologists
Citation: BARRAL-NETTO, M. et al. Up-regulation of T helper 2 and down-regulation of T helper 1 cytokines during murine retrovirus-induced immunodeficiency syndrome enhances susceptibility of a resistant mouse strain to Leishmania amazonensis. American Journal of Pathology, v. 146, n. 3, p. 635-651, 1995.
ISSN: 0002-9440
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Barral-Netto M Up-regulation of th2....pdf1.83 MBAdobe PDFThumbnail
View/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.