Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7621
Title: Granulocytes in the inflammatory process of BALB/c mice infected by Leishmania amazonensis. A quantitative approach.
Authors: Pompeu, Margarida Maria de Lima
Freitas, Luiz Antonio Rodrigues de
Santos, M. L. V
Khouri, M
Barral Netto, Manoel
Affilliation: Universidade Federal do Ceará. Departamentos de Patologia. Fortaleza, CE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, Brasil
Abstract: We used previously immunized (partially resistant) and naive (highly susceptible) BALB/c mice infected with Leishrnania amazonensis for evaluating the role of granulocytes in the course of murine leishmaniasis. The animals were examined at different times post-infection and granulocytes counted in lesion tissues examined ultra-structurally. Polymorphonuclear granulocytes predominated during the early phase of infection and their number decreased with progression of infection; their number was similar in both groups during the early and intermediate phases of infection, though slightly higher in immunized animals during the late phase. Eosinophils represented approximately 10% of cells in the inflammatory infiltrate, being higher during the intermediate phase, and not differing between the groups. Another approach was the evaluation of granulocyte migration to the peritoneal cavity of susceptible BALB/c mice or resistant C57BL/6 mice under several stimuli. There was no statistically significant difference between resistant and susceptible animals in any of the treatments. Despite the influx of granulocytes to the lesion and its possible role in the initial destruction of injected Leishmania, this aspect does not seem to have an important effect on the outcome of the leishmanial infection.
Keywords: Leishmaniasis
Leishmania amazonensis
Granulocytes
Neutrophils
Eosinophils
DeCS: Granulócitos/fisiologia
Leishmaniose/patologia
Animais
Movimento Celular
Modelos Animais de Doenças
Eosinófilos/imunologia
Granulócitos/imunologia
Leishmania/imunologia
Leishmaniose/imunologia
Contagem de Leucócitos
Camundongos
Camundongos Endogâmicos BALB C
Neutrófilos/imunologia
Cavidade Peritoneal/patologia
Fagocitose
Issue Date: 1991
Publisher: Elsevier
Citation: POMPEU, M. L. et al. Granulocytes in the inflammatory process of BALB/c mice infected by Leishmania amazonensis. A quantitative approach. Acta Tropica, v. 48, n. 3, p. 185-193, 1991.
ISSN: 0001-706X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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