Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7624
Title: Histopathologic changes induced by vaccination in experimental cutaneous leishmaniasis of BALB/c mice
Authors: Barral Netto, Manoel
Freitas, Luiz Antonio Rodrigues de
Andrade, Zilton de Araújo
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Highly susceptible BALB/c mice became partially resistant to Leishmania mexicana amazonensis infection after intravenous immunization with solubilized homologous promastigote antigen. Immunized BALB/c mice exhibited mixed mononuclear cell reactions, with granulomatous inflammation, collagen deposition, and fibrinoid necrosis at the site of infection. In contrast, naive animals displayed a monomorphic picture composed of largely vacuolated and parasitized macrophages with areas of coagulative necrosis. Electron microscopy revealed an increased number of eosinophils, sometimes in close contact with parasitized macrophages, in immunized animals. These findings illustrate that histologic changes reflect host immune status in cutaneous leishmaniasis, and that susceptibility of BALB/c mice to L m amazonensis, although dependent on genetic background, can be artificially modified.
DeCS: Antígenos de Protozoários/imunologia
Leishmaniose/patologia
Animais
Hipersensibilidade Tardia
Leishmania mexicana/imunologia
Leishmaniose/imunologia
Macrófagos/patologia
Camundongos
Camundongos Endogâmicos BALB C
Microscopia Eletrônica
Linfócitos T/imunologia
Vacinação
Issue Date: 1987
Publisher: American Association of Pathologists
Citation: ABARRAL-NETTO, M. et al. Histopathologic changes induced by vaccination in experimental cutaneous leishmaniasis of BALB/c mice. American Journal of Pathology, v. 127, n. 2, 1987.
ISSN: 0002-9440
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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