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https://www.arca.fiocruz.br/handle/icict/7652
EFFECT OF NICOTINE TREATMENT AND WITHDRAWAL ON RANDOM-PATTERN SKIN FLAPS IN RATS.
Agonistas Nicotínicos/toxicidade
Pele/efeitos de drogas
Retalhos Cirúrgicos
Sobrevivência de Tecidos/efeitos de drogas
Animais
Modelos Animais de Doenças
Esquema de Medicação
Injeções Subcutâneas
Necrose
Nicotina/administração & dosagem
Agonistas Nicotínicos/administração & dosagem
Ratos
Pele/patologia
Retalhos Cirúrgicos/patologia
Suspensão de Tratamento
Author
Affilliation
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Escola Paulista de Medicina-UNIFESP. São Paulo, SP, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Escola Paulista de Medicina-UNIFESP. São Paulo, SP, Brasil
Escola Paulista de Medicina-UNIFESP. São Paulo, SP, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Escola Paulista de Medicina-UNIFESP. São Paulo, SP, Brasil
Abstract
Background: Tobacco use is associated with a high incidence of skin necrosis after surgery. The ideal timing for the
cessation of tobacco use before plastic surgery has not, however, been precisely determined. The aim of this work was
to define the ideal duration of nicotine withdrawal prior to random-pattern skin flap surgery in rats.
Methods: Groups of 11 animals were subcutaneously injected with saline or nicotine (2 mg/kg) twice a day and
subjected to random-pattern skin flap surgery according to the following protocol: Group I: continuously injected with
saline 4 weeks before and 1 week after the surgery; Group II: injected with nicotine for 4 weeks until the day of the
surgery; Group III: injected with nicotine for 4 weeks until one day before the surgery; Group IV: injected with
nicotine for 4 weeks until 5 days before the surgery; Group V: injected with nicotine for 4 weeks until 10 days before
the surgery; Group VI: continuously injected with nicotine for 4 weeks before and 1 week after the surgery.
McFARLANE skin flaps were performed on the dorsal skin, and the rats were sacrificed 1 week after the surgery.
Results: The necrotic area was smaller in group I (8.85 cm2) than in group II (12.15 cm2), III (12.88 cm2) and VI
(14.84 cm2) (ANOVA po0.0001). There was no difference between groups I, IV (10.13 cm2) and V (9.27 cm2).
Conclusions: In conclusion, 5 days before surgery was considered the ideal time for nicotine withdrawal in this
experimental model.
DeCS
Nicotina/toxicidadeAgonistas Nicotínicos/toxicidade
Pele/efeitos de drogas
Retalhos Cirúrgicos
Sobrevivência de Tecidos/efeitos de drogas
Animais
Modelos Animais de Doenças
Esquema de Medicação
Injeções Subcutâneas
Necrose
Nicotina/administração & dosagem
Agonistas Nicotínicos/administração & dosagem
Ratos
Pele/patologia
Retalhos Cirúrgicos/patologia
Suspensão de Tratamento
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