Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7731
Title: Phagocytosis is inhibited by autophagic induction in murine macrophages.
Authors: Lima, José Geraldo Bomfim
Vinhas, Christiana de Freitas
Gomes, Ivana Nunes
Azevedo, Carine Machado
Santos, Ricardo Ribeiro dos
Santos, Marcos André Vannier dos
Veras, Patrícia Sampaio Tavares
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Biologia Parasitária. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, Brasil
Abstract: Recent studies have demonstrated that communication takes place between the autophagic and phagocytic pathways, indicating that the convergence of these two pathways plays an important role in the innate immune response against intracellular microbes. The present study investigated the effect of autophagic induction on the phagocytic capacity of murine macrophages. Autophagy induced by physiological and pharmacological means was shown to reduce the phagocytic capacity of murine macrophages, regardless of cell origin or the nature of the phagocytosed particles themselves. This autophagic inhibitory effect on phagocytosis was shown to be an early and reversible event that results in no loss of cell viability. Furthermore, the data presented herein demonstrate that the induction of autophagy does not affect a macrophage’s capacity to recognize and bind to particles, indicating that autophagy does not inhibit the particle recognition process, even though particle internalization is suppressed. The findings herein support the notion that phagocytosis and autophagy may be interdependent and complementary processes
Keywords: Autophagy
Phagocytosis
Large particles
Starvation
Rapamycin
Macrophage
DeCS: Autofagia
Macrófagos/fisiologia
Fagocitose
Animais
Linhagem Celular
Leishmania
Macrófagos/microbiologia
Macrófagos/parasitologia
Camundongos
Camundongos Endogâmicos BALB C
Saccharomyces cerevisiae
Issue Date: 2011
Publisher: Elsevier
Citation: LIMA, J. G. B. et al. Phagocytosis is inhibited by autophagic induction in murine macrophages. Biochemical and Biophysical Research Communications, v. 405, n. 4, p. 604-609, 2011.
DOI: 10.1016/j.bbrc.2011.01.076
ISSN: 1090-2104
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Lima JGB Phagocytosis is....pdf817.04 kBAdobe PDFThumbnail
View/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.