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PUERPERAL BRAIN CRYPTOCOCCOMA IN AN HIV-NEGATIVE WOMAN
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Abstract
Cryptococcus spp. cerebral abscesses are uncommon in immunocompetent subjects. The recommended induction treatment is
the administration of amphotericin B plus fl ucytosine combined with resection for lesions ≥3cm. In this paper, we describe an
HIV-negative woman diagnosed with a large cryptococcoma in the immediate postpartum period. The lesion was not resected,
and due to amphotericin B intolerance, she received an extended course of fl uconazole monotherapy. There was no disease
recurrence during the 4 years of follow-up. The abrupt onset of her symptoms following delivery suggests that she developed a
postpartum immune reconstitution syndrome. This case also demonstrates that in specifi c situations fl uconazole monotherapy
can be attempted in immunocompetent patients with cryptococcoma
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