Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7812
Title: Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients.
Authors: Cotrim, Helma Pinchemel
Freitas, Luiz Antonio Rodrigues de
Alves, Erivaldo
Almeida, Alessandro de Moura
May, Daniel Simões
Caldwell, Stephen H.
Affilliation: Universidade Federal da Bahia. Postgraduate Course in Medicine and Health (PPGMS). Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Center for the Surgical Treatment of Obesity. Salvador, BA, Brasil
Universidade Federal da Bahia. Postgraduate Course in Medicine and Health (PPGMS). Salvador, BA, Brasil
Universidade Federal da Bahia. Postgraduate Course in Medicine and Health (PPGMS). Salvador, BA, Brasil
Division of GI/Hepatology. University of Virginia. Charlottesville, USA
Abstract: OBJECTIVES: The effect of light-to-moderate alcohol consumption (LMAC) in nonalcoholic fatty liver disease (NAFLD) remains a controversial subject. The aim of this study was to evaluate the relationship between LMAC and the severity of NAFLD in morbidly obese patients. METHODS: We studied 132 patients undergoing liver biopsy during bariatric surgery. The patients were divided into three groups: G1: alcohol intake greater than 20 g/day and less than 40 g/day; G2: alcohol intake less than 20 g/day; G3: no alcohol intake. Insulin resistance was defined by the Homeostasis Model Assessment (>3). NAFLD was classified according to the Matteoni types: type I: steatosis alone; type II: steatosis with inflammation; types III-IV: steatosis with ballooning and/or fibrosis. RESULTS: The mean age was 37.3+/-11 years. Sixty-three percent were females and body mass index was 43.9+/-5.6 kg/m. G1, G2, and G3 included 19, 56, and 57 patients, respectively. Histological diagnoses classified by levels of alcohol were: G1: 10.5% normal liver, 89.5% type III or IV; G2: 10.7% normal liver, 1.8% type I or II, and 87.5% grade III or IV; G3: 10.5% normal liver, 3.5% type I or II, and 86% type III or IV (one had cirrhosis). The presence of IR was similar in moderate and no alcohol consumption (81.3 and 78.7%) but significantly less in the light consumption group (54%, P<0.05). CONCLUSION: The results suggest that LMAC may have a protection effect against IR in severely obese patients. However, it had no impact on the severity of activity and stage of liver disease.
Keywords: Alcoholic liver disease
Insulin resistance
Nonalcoholic fatty liver disease
Obesity
DeCS: Consumo de Bebidas Alcoólicas/efeitos adversos
Fígado Gorduroso/patologia
Obesidade Mórbida/complicações
Adulto
Idoso
Cirurgia Bariátrica
Índice de Massa Corporal
Estudos Transversais
Fígado Gorduroso/quimioterapia
Feminino
Humanos
Resistência à Insulina/fisiologia
Masculino
Meia-Idade
Obesidade Mórbida/quimioterapia
Adulto Jovem
Issue Date: 2009
Publisher: Lippincott Williams & Wilkins
Citation: COTRIM, H. P. et al. Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients. European Journal of Gastroenterology & Hepatology, v. 21, n. 9, p. 969-972, 2009.
ISSN: 1473-5687
10.1097/MEG.0b013e328328f3ec
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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