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https://www.arca.fiocruz.br/handle/icict/7870
BODY MASS INDEX AND WAIST CIRCUMFERENCE IN NON-ALCOHOLIC FATTY LIVER DISEASE.
Non-alcoholic fatty liver disease
Non-alcoholic steatohepatitis
Waist circumference
Fígado Gorduroso/fisiopatologia
Síndrome X Metabólica/etiologia
Obesidade/fisiopatologia
Relação Cintura-Quadril
Adulto
Alanina Transaminase/sangue
Aspartato Aminotransferases/sangue
Fígado Gorduroso/sangue
Feminino
Humanos
Resistência à Insulina/fisiologia
Fígado/enzimologia
Masculino
Síndrome X Metabólica/sangue
Meia-Idade
Obesidade/sangue
gama-Glutamiltransferase/sangue
Author
Affilliation
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Abstract
OBJECTIVE: To evaluate the association of anthropometric indexes (body mass index and waist circumference) in patients with non-alcoholic fatty liver disease (NAFLD), and its association with insulin resistance (IR), metabolic syndrome (MS) and histological findings. METHODS: From August 2003 to July 2004 a case series of 81 outpatients with clinic and/or histological diagnosis of NAFLD were selected at the Bahia University Gastro-Hepatology Clinic, Brazil. Liver function tests, lipid profile, glucose and insulin were performed in all patients. Body mass index (BMI) and waist circumference (WC) were determined according to WHO criteria. IR was measured by means of the homeostasis model assessment (HOMA) and IR was considered with HOMA > or =3. MS was defined according to the Adult Treatment Panel III (ATP III). Liver biopsy was performed in 37 cases. RESULTS: Body mass index > or = 30 kg m(-2) (obesity) was found in 39% of the cases and BMI > or = 25-29.9 kg m(-2) (overweight) in 53%. BMI was correlated with IR (r = 0.29; P = 0.02) and WC with ALT (r = 0.02; P = 0.03). Increased WC also was related to IR and to MS. The presence of steatohepatitis with fibrosis on liver biopsy was associated with overweight (68%) and increase of WC (41%). CONCLUSIONS: Body mass index and WC are frequent associated with MS, IR and histological findings (steatohepatitis and fibrosis) in patients with NAFLD.
Keywords
Body mass indexNon-alcoholic fatty liver disease
Non-alcoholic steatohepatitis
Waist circumference
DeCS
Índice de Massa CorporalFígado Gorduroso/fisiopatologia
Síndrome X Metabólica/etiologia
Obesidade/fisiopatologia
Relação Cintura-Quadril
Adulto
Alanina Transaminase/sangue
Aspartato Aminotransferases/sangue
Fígado Gorduroso/sangue
Feminino
Humanos
Resistência à Insulina/fisiologia
Fígado/enzimologia
Masculino
Síndrome X Metabólica/sangue
Meia-Idade
Obesidade/sangue
gama-Glutamiltransferase/sangue
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