Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7880
Title: Non-alcoholic fatty liver disease and insulin resistance: importance of risk factors and histological spectrum.
Authors: Siqueira, Ana Cristina Guidorizzi de
Cotrim, Helma Pinchemel
Rocha, Raquel
Carvalho, Fernando Martins
Freitas, Luiz Antonio Rodrigues de
Barreto, Danyella
Gouveia, Leandro
Landeiro, Luciana
Affilliation: Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Abstract: BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has been associated with several metabolic conditions (MC) and secondary causes, but the relationship between insulin resistance (IR) and the underlying aetiology of NAFLD has not been extensively explored. OBJECTIVE: To determine the frequency of IR among NAFLD patients and to describe IR according to risk factors and histological findings of the disease. METHODOLOGY: A case-series study of 64 patients with clinical and histological diagnosis of NAFLD. IR was calculated by homeostasis model assessment (HOMA) and IR was considered when HOMA > or = 3. Histological grades of NAFLD were: stage 1, steatosis isolated; stage 2, steatosis and inflammation; stage 3, steatosis and ballooning degeneration; stage 4, steatosis and fibrosis and/or Mallory bodies. Fibrosis was graded 0-4 (cirrhosis). RESULTS: IR was found in 21 (33%) patients. Among those with IR, 16 patients (76%) had associated MC and five patients (24%) had exposure to petrochemicals. The mean value of HOMA varied from 3.5 in NAFLD associated with MC to 1.6 in patients with exposure to petrochemicals (P < 0.03). Waist circumference was the metabolic factor most strongly associated with IR (P < 0.005). Steatohepatitis (NASH) was observed in 54 (84.3%) cases. The HOMA mean value was significantly higher in patients with advanced fibrosis. CONCLUSIONS: IR occurred in 33% of the NAFLD patients, being more frequent among those with MC than among those with exposure to petrochemicals. The presence of IR in cases with advanced fibrosis suggests that it may influence the prognosis of NAFLD.
Keywords: Non-alcoholic fatty liver disease
Non-alcoholic steatohepatitis
Insulin resistance
DeCS: Fígado Gorduroso/fisiopatologia
Resistência à Insulina/fisiologia
Adulto
Doença Crônica
Fígado Gorduroso/sangue
Fígado Gorduroso/patologia
Feminino
Humanos
Cirrose Hepática/sangue
Cirrose Hepática/patologia
Cirrose Hepática/fisiopatologia
Masculino
Síndrome X Metabólica/sangue
Síndrome X Metabólica/patologia
Síndrome X Metabólica/fisiopatologia
Meia-Idade
Fatores de Risco
Issue Date: 2005
Publisher: Lippincott Williams & Wilkins
Citation: GUIDORIZZI DE SIQUEIRA, A. C. et al. Non-alcoholic fatty liver disease and insulin resistance: importance of risk factors and histological spectrum. European Journal of Gastroenterology & Hepatology, v. 17, n. 8, p. 837-841, 2005.
ISSN: 0954-691X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Siqueira ACG Non-alcogolic....pdf81.16 kBAdobe PDFView/Open



FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.