Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7896
Title: Therapeutic response to thalidomide in Melkersson-Rosenthal syndrome: a case report.
Authors: Medeiros Junior, Manoel
Araujo, Maria Ilma
Guimarães, Newton Sales
Freitas, Luiz Antonio Rodrigues de
Silva, Tânia Maria Correia
Carvalho Filho, Edgar Marcelino
Affilliation: Hospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil
Hospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Division of Dermatology. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Escola Baiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Abstract: BACKGROUND: Melkersson-Rosenthal syndrome (MRS) is a rare disorder of unknown etiology characterized by a triad of symptoms: recurrent orofacial swelling, relapsing facial palsy. and a fissured tongue. A differential diagnosis must be made with other granulomatous diseases, such as sarcoidosis and oral Crohn disease; however, the histologic findings of noncaseating, sarcoidal granulomas support the diagnosis of MRS. RESULTS: Many therapeutic modalities have been described for this disease. In this case report, we present a patient with MRS that was treated with thalidomide because of the identification of tumor necrosis factor a in the lesion by immunohistochemical analysis. This is the first reported detection of tumor necrosis factor a in an MRS lesion, as well the first reported use of thalidomide to treat this clinical condition
DeCS: Imunossupressores/uso terapêutico
Síndrome de Melkersson-Rosenthal/quimioterapia
Talidomida/uso terapêutico
Fator de Necrose Tumoral alfa/antagonistas & inibidores
Adolescente
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/uso terapêutico
Biópsia
Dexametasona/administração & dosagem
Dexametasona/uso terapêutico
Quimioterapia Combinada
Humanos
Quimioterapia Combinada
Lábio/química
Masculino
Síndrome de Melkersson-Rosenthal/metabolismo
Indução de Remissão
Talidomida/administração & dosagem
Fator de Necrose Tumoral alfa/análise
Issue Date: 2002
Publisher: Elsevier
Citation: MEDEIROS JUNIOR, M. et al. Therapeutic response to thalidomide in Melkersson-Rosenthal syndrome: a case report. Annals of Allergy, Asthma and Immunology, v. 88, n. 4, p. 421-424, 2002.
ISSN: 1081-1206
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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