Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7908
Title: Leishmania amazonensis infection: a comparison of in vivo leishmanicidal mechanisms between immunized and naive infected
Authors: Pompeu, Margarida Maria de Lima
Freitas, Luiz Antonio Rodrigues de
Santos, M. L. V
Barral, Aldina Maria Prado
Barral Netto, Manoel
Affilliation: Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Abstract: In vitro studies have shown that both macrophage activation and destruction of parasitized macrophages lead to leishmania destruction. The relative role played by such mechanisms in vivo have not been properly evaluated. We took advantage of the model of intravenous immunization with solubilized leishmanial antigen which renders partially resistant the otherwise highly susceptible BALB/c mice to address this issue avoiding the interference of different genetic backgrounds. Leishmania destruction occurred in three situations: destruction of the parasitized macrophage, which were in close contact with lymphocytes or eosinophils; extracellular damage, always surrounded by small foci of granulocytes; and parasite damage inside activated macrophages. Destruction of the parasitized macrophages was frequently seen in immunized and protected animals. Our observations suggest that destruction of parasite-loaded macrophages is an important mechanism of host protection in experimental cutaneous leishmaniasis.
Keywords: Leishmania amazonensis;
Leishmaniasis
Immunization
Leishmania
Tegumentary leishmaniasis
Experimental leishmaniasis
DeCS: Imunização
Leishmania mexicana/imunologia
Leishmaniose Cutânea/imunologia
Ativação de Macrófagos
Macrófagos/imunologia
Animais
Eosinófilos/imunologia
Granulócitos/imunologia
Leishmania mexicana/ultraestrutura
Macrófagos/parasitologia
Camundongos
Camundongos Endogâmicos BALB C
Microscopia Eletrônica
Issue Date: 1992
Publisher: Academic Press Inc.
Citation: POMPEU, M. L. et al. Leishmania amazonensis infection: a comparison of in vivo leishmanicidal mechanisms between immunized and naive infected. Experimental Parasitology, v. 74, n. 2, p. 169-176, 1992.
ISSN: 0014-4894
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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