Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7910
Title: Distinct ultrastructural aspects in different biopsies of a single patient with diffuse cutaneous leishmaniasis
Authors: Bittencourt, Achilea Candida Lisboa
Freitas, Luiz Antonio Rodrigues de
Pompeu, Margarida Maria de Lima
Vieira, Maria Lucia
Barral, Aldina Maria Prado
Affilliation: Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Anatomia Patologica. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.
Universidade Federal do Ceará. Departamento de Patologia. Fortaleza, CE, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Laboratório de Imunologia. Salvador, BA, Brasil.
Abstract: The authors investigated the relation between parasites and host-cells in active and regressed lesions of a patient with diffuse cutaneous leishmaniasis, evaluating the frequency of different cell types, and the location and integrity of amastigotes. No correlation was found between parasite integrity and size of parasitophorous vacuoles. They observed ultrastructural findings characterizing a cell mediated immune response: macrophages lysis, parasitic destruction inside macrophages, close contact between parasitized macrophages and lymphocytes and between parasites and lymphocytes, lymphocytic infiltration and fibrosis. They suggest that in DCL there is a limited cellular immune response, although insufficient to control infection.
Keywords: Diffuse cutaneous leishmaniasis
Human leishmaniasis
Leishmania
Skin biopsie
DeCS: Leishmaniose/patologia
Pele/ultraestrutura
Adulto
Animais
Biópsia
Humanos
Leishmania/isolamento & purificação
Leishmaniose/parasitologia
Macrófagos/parasitologia
Macrófagos/ultraestrutura
Masculino
Issue Date: 1990
Publisher: Fiocruz
Citation: BITTENCOURT, Achilea Candida Lisboa et al. Distinct ultrastructural aspects in different biopsies of a single patient with diffuse cutaneous leishmaniasis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 85, n. 1, p. 53-59, 1990.
DOI: 10.1590/S0074-02761990000100008
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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