Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7912
Title: Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study
Authors: Andrade, Sonia Gumes
Silva, R. C.
Santiago, Christiane Maria Gaspar
Freitas, Luiz Antonio Rodrigues de
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.
Universidade Federal da Bahia. Salvador, BA, Brasil.
Universidade Federal da Bahia. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.
Abstract: The anti-protozoal drug MK-436 (3-(J-methyl-5-nitroimidazol-2-yl)-3a,4,5,6,7,7ahexahydro-1,2-benzisoxazole) was found to be effective against Trypanosoma cruzi infections in mice (2 daily doses of250 mg per kg body weight). Parasitaemia disappeared within 24 hours oftreatment which was commenced during the early or late stages ofacute infection. Intracellular T. cruzi parasites were also affected by the drug, ultrastructural findings showing severe cytoplasmic vacuolization and membrane alterations. Positive serological responses persisted in the majority oftreated and parasitologically cured mice in the study. Cure rates varied from 72% to 100% and were similar regardless of the T. cruzi strain used (Y strain, type 1; 12 SF strain, type II; or Colombian strain, type III). However, the proportion ofpositive serological tests and the frequency of inflammatory lesions were greatestfor mice that were infected with the Colombian strain ofthe parasite.
DeCS: Doença de Chagas/quimioterapia
Modelos Animais de Doenças
Nitroimidazóis/uso terapêutico
Tripanossomicidas/uso terapêutico
Animais
Cardiomiopatia Chagásica/parasitologia
Cardiomiopatia Chagásica/patologia
Doença de Chagas/parasitologia
Doença de Chagas/patologia
Feminino
Masculino
Camundongos
Miocárdio/ultraestrutura
Tripanossomicidas/farmacologia
Trypanosoma cruzi/efeitos de drogas
Trypanosoma cruzi/ultraestrutura
Issue Date: 1987
Publisher: World Health Organization
Citation: ANDRADE, S. G. et al. Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study. Bulletin of the World Health Organization, v. 65, n. 5, p. 625-633, 1987.
ISSN: 0042-9686
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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