Author | Gonçalves, Marilda de Souza | pt_BR |
Author | Moura Neto, José Pereira de | pt_BR |
Author | Souza, C. L. | pt_BR |
Author | Melo, P. | pt_BR |
Author | Reis, Mitermayer Galvão dos | pt_BR |
Access date | 2014-07-14T16:16:56Z | |
Available date | 2014-07-14T16:16:56Z | |
Document date | 2010 | |
Citation | GONÇALVES, M. S. et al. Evaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia. International Journal of Laboratory Hematology, v. 32, n. 1 Pt 1, p. e49-56, 2010. | pt_BR |
ISSN | 1751-553X | |
URI | https://www.arca.fiocruz.br/handle/icict/7948 | |
Language | eng | pt_BR |
Publisher | Blackwell Publishing | pt_BR |
Rights | open access | pt_BR |
Title | Evaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1111/j.1751-553X.2009.01169.x | |
Abstract | Glutathione S-transferase (GST) enzymes protect cells against xenobiotics
and oxidative stress products through an electrophilic conjugation
process. We investigated the theta (GSTT1) and mu (GSTM1) null
genotypes in a group of leukopenic subjects and normal subjects from
Northeast Brazil, evaluating their use as biomarkers of susceptibility for
developing leukopenia. In a sample-based case–control study, we
analysed white blood cell (WBC) counts and GSTT1 and GSTM1
genotypes. A total of 278 subjects were analysed: 91 with leukopenia
and 187 controls. GSTT1 null genotype conferred a 5.92-fold risk for
occurrence of leukopenia [odds ratios (OR) = 5.92, CIMLE: 1.64–26.72,
PMLE = 0.002] and a 3.90-fold risk of neutropenia (OR = 3.90; CIMLE:
1.05–13.66; PMLE = 0.02), while GSTM1 null genotype conferred a
1.78-fold risk for leukopenia (OR = 1.75; CIMLE: 1.04–3.06,
PMLE = 0.017) and no risk of neutropenia (OR = 1.71; CIMLE: 0.88–
3.35; PMLE = 0.06). The GSTT1, but not the GSTM1 null genotype, was
found to be associated with leukopenia and neutropenia. More cellular
and molecular studies are needed to evaluate the existence of genotype
interactions, and to confirm the appropriateness of using the GSTT1
and/or GSTM1 null genotypes as biomarkers of susceptibility to white
blood-cell deficiencies. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Pathology and Molecular Biology Laboratory. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Department of Clinical and Toxicology Analyses. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Pathology and Molecular Biology Laboratory. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Department of Clinical and Toxicology Analyses. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Pathology and Molecular Biology Laboratory. Salvador, BA, Brasil / Laboratório de Análises Clínicas Labchecap. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Pathology and Molecular Biology Laboratory. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Pathology and Molecular Biology Laboratory. Salvador, BA, Brasil | pt_BR |
Subject | Glutathione S-transferase | pt_BR |
Subject | Leukopenia | pt_BR |
Subject | Ethnic group | pt_BR |
Subject | Biomarker | pt_BR |
Subject | Leukocytes | pt_BR |
DeCS | Marcadores Biológicos/sangue | pt_BR |
DeCS | Glutationa Transferase/genética | pt_BR |
DeCS | Leucopenia/genética | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Brasil | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Deleção de Genes | pt_BR |
DeCS | Predisposição Genética para Doença | pt_BR |
DeCS | Genótipo | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Masculino | pt_BR |