Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7948
Title: Evaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia.
Authors: Gonçalves, Marilda de Souza
Moura Neto, José Pereira de
Souza, C. L.
Melo, P.
Reis, Mitermayer Galvão dos
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Pathology and Molecular Biology Laboratory. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Department of Clinical and Toxicology Analyses. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Pathology and Molecular Biology Laboratory. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Department of Clinical and Toxicology Analyses. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Pathology and Molecular Biology Laboratory. Salvador, BA, Brasil / Laboratório de Análises Clínicas Labchecap. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Pathology and Molecular Biology Laboratory. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Pathology and Molecular Biology Laboratory. Salvador, BA, Brasil
Abstract: Glutathione S-transferase (GST) enzymes protect cells against xenobiotics and oxidative stress products through an electrophilic conjugation process. We investigated the theta (GSTT1) and mu (GSTM1) null genotypes in a group of leukopenic subjects and normal subjects from Northeast Brazil, evaluating their use as biomarkers of susceptibility for developing leukopenia. In a sample-based case–control study, we analysed white blood cell (WBC) counts and GSTT1 and GSTM1 genotypes. A total of 278 subjects were analysed: 91 with leukopenia and 187 controls. GSTT1 null genotype conferred a 5.92-fold risk for occurrence of leukopenia [odds ratios (OR) = 5.92, CIMLE: 1.64–26.72, PMLE = 0.002] and a 3.90-fold risk of neutropenia (OR = 3.90; CIMLE: 1.05–13.66; PMLE = 0.02), while GSTM1 null genotype conferred a 1.78-fold risk for leukopenia (OR = 1.75; CIMLE: 1.04–3.06, PMLE = 0.017) and no risk of neutropenia (OR = 1.71; CIMLE: 0.88– 3.35; PMLE = 0.06). The GSTT1, but not the GSTM1 null genotype, was found to be associated with leukopenia and neutropenia. More cellular and molecular studies are needed to evaluate the existence of genotype interactions, and to confirm the appropriateness of using the GSTT1 and/or GSTM1 null genotypes as biomarkers of susceptibility to white blood-cell deficiencies.
Keywords: Glutathione S-transferase
Leukopenia
Ethnic group
Biomarker
Leukocytes
DeCS: Marcadores Biológicos/sangue
Glutationa Transferase/genética
Leucopenia/genética
Adulto
Brasil
Feminino
Deleção de Genes
Predisposição Genética para Doença
Genótipo
Humanos
Masculino
Issue Date: 2010
Publisher: Blackwell Publishing
Citation: GONÇALVES, M. S. et al. Evaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia. International Journal of Laboratory Hematology, v. 32, n. 1 Pt 1, p. e49-56, 2010.
DOI: 10.1111/j.1751-553X.2009.01169.x
ISSN: 1751-553X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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