Mostrar el registro sencillo del ítem

AutorBlangero, Sarah Williams
AutorCriscione, Charles D.
AutorVandeBerg, John L.
AutorOliveira, Rodrigo Corrêa de
AutorWilliams, Kimberly D.
AutorSubedi, Janardan
AutorKent Jr., Jack W.
AutorWilliams, Jeff
AutorKumar, Satish
AutorBlangero, John
Fecha de acceso2014-07-18T14:37:13Z
Fecha de disponibilización2014-07-18T14:37:13Z
Fecha de publicación2012
ReferenciaWILLIAMS-BLANGERO, Sarah et al. Host genetics and population structure effects on parasitic disease. Philosophical Transactions of the Royal Society. 2012, vol. 367, pp. 887-894.pt_BR
ISSN0962-8436
URIhttps://www.arca.fiocruz.br/handle/icict/7996
Idiomaengpt_BR
EditorThe Royal Societypt_BR
Derechos de autoropen accesspt_BR
TítuloHost genetics and population structure effects on parasitic diseasept_BR
Tipo del documentoArticlept_BR
DOI10.1098/rstb.2011.0296
Resumen en InglésHost genetic factors exert significant influences on differential susceptibility to many infectious diseases. In addition, population structure of both host and parasite may influence disease distribution patterns. In this study, we assess the effects of population structure on infectious disease in two populations in which host genetic factors influencing susceptibility to parasitic disease have been extensively studied. The first population is the Jirel population of eastern Nepal that has been the subject of research on the determinants of differential susceptibility to soil-transmitted helminth infections. The second group is a Brazilian population residing in an area endemic for Trypanosoma cruzi infection that has been assessed for genetic influences on differential disease progression in Chagas disease. For measures of Ascaris worm burden, within-population host genetic effects are generally more important than host population structure factors in determining patterns of infectious disease. No significant influences of population structure on measures associated with progression of cardiac disease in individuals who were seropositive for T. cruzi infection were found.pt_BR
AfiliaciónTexas Biomedical Research Institute. Department of Genetics. San Antonio, TX, USApt_BR
AfiliaciónTexas A&M University. Department of Biology. College Station, TX, USApt_BR
AfiliaciónTexas Biomedical Research Institute. Department of Genetics. San Antonio, TX, USA/Southwest National Primate Research Center. San Antonio, TX, USApt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasilpt_BR
AfiliaciónTemple University. Department of Anthropology. Philadelphia, PA, USApt_BR
AfiliaciónMiami University. Department of Sociology and Gerontology. Oxford, OH, USApt_BR
AfiliaciónTexas Biomedical Research Institute. Department of Genetics. San Antonio, TX, USApt_BR
AfiliaciónTexas Biomedical Research Institute. Department of Genetics. San Antonio, TX, USApt_BR
AfiliaciónTexas Biomedical Research Institute. Department of Genetics. San Antonio, TX, USApt_BR
AfiliaciónTexas Biomedical Research Institute. Department of Genetics. San Antonio, TX, USApt_BR
Palavras clave en Inglêspopulation structurept_BR
Palavras clave en Inglêsgenetics of infectious disease susceptibilitypt_BR
Palavras clave en Inglêsintestinal wormspt_BR
Palavras clave en InglêsChagas diseasept_BR


Ficheros en el ítem

application/pdf
Nombre:
Host genetics and population ...
Tamaño:
137.5Kb
Formato:
application/
Ver/Abrir

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem