| Author | Barreto, Fernanda Khouri | |
| Author | Rego, Felipe Ferreira de Almeida | |
| Author | Fonseca, Loianna M. | |
| Author | Castro Filho, Bernardo Galvão | |
| Author | Araújo, Thessika Hialla Almeida | |
| Author | Miranda, Aline Cristina Andrade Mota | |
| Author | Cunha, Joana Paixão Monteiro | |
| Author | Alcantara, Luiz Carlos Júnior | |
| Access date | 2014-07-23T17:56:20Z | |
| Available date | 2014-07-23T17:56:20Z | |
| Document date | 2013 | |
| Citation | BARRETO, F. K. et al. Molecular characterization of the human T cell lymphotropic virus type 2 long terminal repeat region: A discussion about possible influences at viral gene expression. AIDS Research Human Retroviruses, v. 30, n. 1, p. 92-96, 2014. | pt_BR |
| ISSN | 1931-8405 | |
| URI | https://www.arca.fiocruz.br/handle/icict/8068 | |
| Language | eng | pt_BR |
| Publisher | Mary Ann Liebert, Inc | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Virus linfotropico T humano tipo 2 | pt_BR |
| Subject in Portuguese | HTLV-2 | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Subject in Portuguese | Reação em cadeia da polimerase | pt_BR |
| Subject in Portuguese | PCR | pt_BR |
| Subject in Portuguese | Filogenia | pt_BR |
| Subject in Portuguese | Polimorfismo | pt_BR |
| Title | Molecular characterization of the human T cell lymphotropic virus type 2 long terminal repeat region: A discussion about possible influences at viral gene expression | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1089/aid.2013.0181 | |
| Abstract | This study aimed to identify nucleotide signatures in the promoter region of human T cell lymphotropic virus
type 2 (HTLV-2) isolated from infected individuals from Salvador, Brazil and in sequences from the GenBank
database. DNA samples from HTLV-2-infected individuals were submitted to nested polymerase chain reaction
(PCR) and sequencing, and molecular analyses were performed using bioinformatics tools. The phylogeny of
HTLV-2 strains isolated from patients from Salvador reveals that all sequences were subtype c. One hundred
and fifty-one sequences from GenBank were selected, among which 30 belong to subtype a, 88 to subtype b, 32 to
subtype c, and one to subtype d. Subtype-specific signatures were identified as well as mutations resulting in
loss or gain of motifs important to transcription regulation. The subtypes a and b have two E box motifs, while
subtypes c and d have only one. These polymorphisms may impact viral fitness and infection outcome and
should be more closely investigated. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil. | pt_BR |
